Western Of Guangxi Homocysteine Correlation With Cardiac Structure And Function In Chronic Kidney Disease Patients

Object:We investigate the chronic kidney disease (CKD) in blood homocysteine (Hcy) levels;The Hcy levels relationship with cardiovascular risk factors in patients with CKD;Hcy levels relationship with cardiac structure and function in CKD patients.Method:Retrospective analysis of the December 2012 to January 2015 in the Affiliated Hospital of Youjiang Medical College Nephrology clinical data of patients hospitalized. Analysis of the normal and population of patients with CKD differences between Hcy levels, CKD at different stages of blood Hcy levels and age and gender are two uncontrollable factors affecting Hcy levels, Then analyzed the normal group and between the cases of cardiac structure and function of the difference. According elevated Hcy were divided into high and normal Hcy nephropathy and compared between the levels of cardiovascular risk factors, then analyzed differences in cardiovascular structure and function indicators comparison between the two groups. Finally, the Hcy levels with the risk factors and cardiac structure and function to linear correlation.Results:Chronic kidney disease (CKD) patients with a high prevalence of blood homocysteine (HHcy) disease compared with a statistically significant (p<0.01) and normal subjects, In the normal group, men Hey levels than women, statistically significant (p<0.05), But in CKD patients, men and women are not statistically significant (p> 0.05), In the age group, the middle-aged group of Hey levels higher than the youth group was statistically significant (p<0.05). In more normal group and the patient group of other risk factors in, Hb, creatinine, systolic blood pressure, diastolic blood pressure, eGFRare present differences (p <0.05), Comparison with normal patient group, the left atrium (LA), left ventricular (LV), the internal carotid artery intima-media thickness (IMT), ejection fraction (EF) There were significant differences (p<0.05);Hcy increased nephropathy (Hcy> 15 mmol/L) in serum creatinine higher than normal Hey nephropathy (Hey<15mmol/L), the difference was statistically significant (p <0.01), The glomerular filtration rate (eGFR), hemoglobin (Hb) lower than normal Hey nephropathy group, the difference was statistically significant (p <0.05), Two systolic blood pressure, diastolic blood pressure was no significant difference (p> 0.05), The increase in Hey nephropathy compared to normal kidney group and Hey in, LA, LV, IMT, EF were no statistically significant. Hey levels in line with the risk factors Spearman linear correlation analysis, Hey and Hb, eGFR was negatively correlated (p<0.05), and Cr, systolic blood pressure, diastolic blood pressure, was positively correlated (p<0.05); Finally, Hey and cardiovascular structure and function indicators give a Spearman correlation analysis, Hey levels and LA, LV, IMT was positively correlated (p <0.05), and EF was negatively correlated with the difference was not statistically significant (p> 0.05).Conclusion:Prevalence of CKD in patients with high homocysteine, Elevated Hey levels and Cr, systolic blood pressure, diastolic blood pressure was positively correlated (p<0.05), and Hb and eGFR was negatively correlated (p <0.05); Hcy chronic kidney disease and cardiovascular structures are closely linked, Hcy levels and LA, LV, IMT was positively correlated (p<0.05), can predict changes in cardiovascular structure However, in patients with CKD not high Hcy hyperlipidemia main factors leading to changes in the cardiovascular system. Besides the normal population Hcy levels can be affected by both age and gender.