Correlational Research Between Glycated Hemoglobin And The Severity Of Coronary Arterial Stenosis In Patients With Coronary Heart Disease And Type 2 Diabetes

Background and Objective:Coronary heart disease is the leading cause of death globally in non-communicable diseases,the incidence rate is still on the rise in China,while the gold standard for diagnosis of coronary heart disease is the invasive coronary angiography.Diabetes is one of the major risk factors for coronary heart disease,the incidence of diabetes has increased year by year.Therefore,the main aim of this study,when one has coronary heart disease with type 2 diabetes,was to analysis the relevance of coronary arterial stenosis and glycated hemoglobin.Methods: A retrospective study was conducted on 1197 patients,having coronary heart disease and type 2 diabetes,who firstly underwent their coronary angiography between January 2011 and December 2018 in the first hospital of Lanzhou university.Collecting their clinical records.Estimating the severity of coronary arterial stenosis by Gensini score.Performing statistical analysis,these indicators included clinical and laboratory parameters,by SPSS software(version 23.0).Results:The gender ratio in 1197 patients is 2.80 men per women,accounting for 52.8% of smoking,hypertension accounts for 60.7%,the proportion of overweight and obesity is 59.0%.Glycated hemoglobin%(7.84±1.55),glycosylated hemoglobin between men and women is not statistically significant(P = 0.68),the levels(P = 0.015)of glycated hemoglobin is lower in summer(7.68±1.42)than spring(8.04±1.71),Gensini score is correlated(P <0.05)with glycated hemoglobin,body mass index,heart rate,white blood cells,low-density lipoprotein,homocysteine,fasting blood glucose,left ventricular ejection fraction,left ventricular end-diastolic volume,smoking,systolic blood pressure,total cholesterol and uric acid.Gensini score does not have an association(P > 0.05)with diastolic blood pressure,red blood cells,hemoglobin,platelets,creatinine,high-density lipoprotein,triglycerides,age and hypertension.Conclusions: 1.In coronary heart disease with type 2 diabetic patients,glycated hemoglobin has a positive correlation with Gensini score(r=0.075,P <0.05).2.Evaluating the severity of coronary arterial stenosis in patients with coronary heart disease and type 2 diabetes is limited by glycated hemoglobin(R square = 0.7%).