The Relationship Between Glycosylated Hemoglobin Level And Coronary Lesion In Patients With Non-diabetic Coronary Heart Diseases

Objective: To examine the relationship between Hb A1 c level and coronary lesion in patients with non-diabetic coronary heart disease.Methods:In this study,we retrospectively grouped 93 patients with non-diabetic CHD who admitted in the First Affiliated Hospital of Dalian Medical University from May 2014 to February 2015.And other 91 patients with negtive coronary angiography during the same period as the control group. The charcateristics of all patients including gender, age, smoking history, hypertension, body mass index(BMI), glycosylated haemoglobin A1c(Hb A1c), fasting plasma glucose(FPG), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), lipoprotein(a)(LP(a)),homocysteine(HCY),blood uric acid(UA) and high sensitivity C- reactive protein(Hs- CRP) were collected. According to the level of glycosylated hemoglobin,the patients were divided into three sub group, which included low level group(n=26, male 22 cases,Hb A1 c ≤ 5.4%), middle level group(n=32, male 24 cases, Hb A1c:5.5-5.7%), and the high level group(n=35, male 19 cases, Hb A1 c ≥ 5.8%).The consequences of coronary angiography were judged by Gensini score. All the data was analysed by sofeware SPSS20.0 statistical software.Results: Compared with control group, patients with non-diabetic coronary heart diseases had significantly raised glycosylated hemoglobin levels(5.7%(4.8%,6.4%)比 5.5%(4.8%,6.2%),P value is 0.007).Among the consequences of coronary angiography of them, 39 cases had single lession(41.9%), 54 cases(58.1%) with double or three vessel lessions, and the other 7 cases(7.5%) suffered from left artery disease. The median of coronary Gensini score was 20(1,116). In this study we applied Spearmon rank correlation analysis to investigate the possible relationship between the coronary heart disease risk factors and coronary Gensini scores. In patients with non-diabetic coronary heart diseases, coronary Gensini score was positively correlated to UA and Hs-CRP(P < 0.05), the correlation coefficient was0.271 and 0.283 respectively. But the Gensini score did not correlated to gender, age,BMI, smoking, hypertension, FPG, TC, TG, HDL-C, LP(a), HCY, Hb A1 c. And there were no significant differences in the number of involved coronary artery among the three goups(P > 0.05), but the Gensini scores among the three groups with a median of 11, 20 and 26 respectively showed differences(P < 0.05). And the Gensini scores increased accompanied by rasied glycosylated hemoglobin.Conclusions: The glycosylated hemoglobin is one of risk factors of coronary atherosclerosis heart disease.In patients with non-diabetic coronary heart diseases,the Gensini scores increased accompanied by rasied glycosylated hemoglobin, but Hb A1 c has no significant correlation with the degree of coronary stenosis lesion.