The Study On The Correlation Between Glycosylated Hemoglobin Level And Coronary Artery Disease In The Patients With Unstable Angina

Objective: By analyzing the level of Hb A1 c in patients with unstable angina, explore the relationship between Hb A1 c levels and coronary artery stenosis severity, and according to the level of prediction of the extent of the coronary artery disease, to guide the clinical work better. In the precondition of avoiding the occurrence of hypoglycemia, the method of manual intervention can reduce the level of Hb A1 c, delay or prevent the CHD and its complications.Methods: Randomly selected the diagnosis of unstable angina patients with CAG operation in parallel, selected a total of 100 cases, 50 cases of male, 50 cases of female,mean age 62.24 ± 5.28 years, except in patients with NSTEMI or STEMI in May to December of 2015 in Shaanxi Province People’s Hospital. Asked detailed history of the patients, including the previous history of hypertension, diabetes history, early morning fasting elbow vein blood test TC, TG, LDL-C, HDL-C, fasting blood glucose, Hb Alc.According to the results of CAG, when three coronary arteries in any a vascular stenosis50%, single vessel disease group, when 2 vascular stenosis 50%, double vessel lesion group(left main coronary artery disease is regarded as a double vessel disease), when 3or more than 3 vascular stenosis degree is more than 50%, for the multi vessel disease group, three vessels failed to find the degree of stenosis is more than 50%, classified as the control group. The control group could be divided into groups: the normal group and the stenosis degree <50% group. When the 3 coronary vessels had 1 or more than 1vessel stenosis degree >50%, they were classified as coronary heart disease group.Comparison of coronary heart disease group and control group between age and sex,smoking, hypertension, diabetes, TG, UA, TC, LDL-C, HDL-C, Hb A1 c, fasting blood glucose level; according to the level of Hb A1 c was divided into 4 subgroups, respectively.Hb A1c<6.0%; Hb A1c[6%-7%]; Hb A1c[7%-8%]; Hb A1 c >8%; calculation between the subgroups of Gensini integral the assessment of the severity of coronary artery disease,patients, and the comparison between the two groups; comparison between groups of gender, age, coronary heart disease, smoking, hypertension, diabetes, TG, UA, TC,LDL-C, HDL-C, Hb A1 c, fasting blood glucose level; than the level of fasting blood glucose, Hb A1 c compared to the normal control group have no significant difference in;Gensini coronary lesion score and Hb A1 c linear correlation analysis to explore the relationship between; with Hb A1 c as independent variables, the incidence of coronary heart disease and not as the dependent variable, a single variable Logistic regression analysis, To explore the statistical significance.Results: 1. According to the level of HbA1 c,Patients with coronary heart disease is divided into four subgroups, each subgroup Gensini score increases with the increase of Hb A1 c value, and there is statistically significant difference between the groups(P<0.05).2. The history of hypertension, diabetes history, Hb A1 c has a statistically significant difference(P<0.05) in the coronary heart disease group.3. Between the normal control group fasting plasma glucose 、 Hb A1 c has a statistically significant(P <0.05)4. Gensini score of coronary artery lesions was positively correlated with Hb A1 c level(r=0.418, P < 0.05).5. Taking Hb A1 c as the independent variable, coronary heart disease occurred or not as the dependent variable, and the single independent variable Logistic Regression analysis, the results of Hb A1 c and coronary score correlation, regression coefficient 0.686.Conclusions:1. Coronary heart disease patients with hypertension history, diabetes history, Hb A1 c, there was statistical significance.2. Hb A1 c and Gensini score is positively correlated inthe coronary heart disease group, and Hb A1 c is the coronary artery disease score independence Influencing factors.3. Fasting blood glucose and Hb A1 c both can affect the occurrence of coronary artery disease, especially in the early stage of coronary heart disease.Section.4. Hb A1 c levels can be considered as an indicator of the severity of coronary artery disease in patients with CHD who did not undergo CAG.