Effect Of Modified Taohong Siwu Decoction On Diabetic Patients With Restless Leg Syndrome And Effect Of Iron Metabolism

Objective:Observe the clinical effect of Jiawei Taohong Siwu Tang on diabetes patients with restless legs syndrome and its effect on iron metabolism.Through the analysis and summary of the observation results,the therapeutic effect of Jiawei Taohong Siwu Decoction is further clarified,and the discussion of Jiawei Taohong Siwu Decoction Correlation between the effect of decoction on diabetes and restless leg syndrome and iron metabolism.Methods:According to the principle of randomization and control in clinical trials,a simple randomization method was used to divide 60 patients who were diagnosed with diabetes and restless leg syndrome and belonged to the syndrome of Yin deficiency and blood stasis syndrome using a random number table.There were 30 cases in the treatment group and the control group was given lifestyle intervention,diabetes education and basic hypoglycemic treatment.The treatment group was combined with Jiawei Taohong Siwu Decoction for 4 weeks,before and after the trial.After the clinical efficacy evaluation.Throughout the course of treatment,monitor changes in fasting blood glucose,2h postprandial blood glucose,glycated hemoglobin,serum iron,serum ferritin,hemoglobin and other relevant indicators,and use TCM syndrome scores and RLS severity self-assessment scale score statistics to evaluate the efficacy.Statistical analysis of all data was performed using SPSS 20 statistical software.Results:?The overall effective rate of the treatment group is 90%,and the overall effective rate of the control group is 10%.The overall clinical efficacy of the treatment group is significantly better than the control group;?After 4 weeks of treatment,the TCM syndrome score and RLS severity of the treatment group The degree of improvement of the rating scale is significantly better than that of the control group(P<0.01).Among the single TCM symptoms,the treatment group has greatly improved the remaining symptoms except for skin nail errors and waist and knee soreness symptoms compared to the control group(P<0.05 or P<0.01);?Glucose metabolism indexes(FBG,PBG,HbA1c)in the treatment group and the control group showed no significant difference before and after treatment(P>0.05),and iron metabolism related indexes in the treatment group(SI,SF,Hb)after 1 month of treatment,there was a significant improvement(P<0.01),while the iron metabolism level of the control group had no significant change(P>0.05).There is a significant difference between the two groups.The treatment group can significantly increase serum iron,ferritin,and hemoglobin levels(P<0.01);?In terms of safety,the blood and urine routines,stool routines,liver and kidney functions and other safety indicators of the subjects in the control and treatment groups before and after treatment are within the normal range.After adjusting the dosage,the symptoms improved and treatment can be continued.Conclusion:After preliminary clinical observation,Jiawei Taohong Siwu Decoction can significantly improve the clinical symptoms and signs of patients with diabetes and restless legs syndrome,and increase the serum iron,ferritin and hemoglobin levels.The mechanism may be related to the level of iron metabolism.The improvement is related,and to a certain extent,it will promote the progress and development of diabetes combined with restless leg syndrome in the field of Chinese medicine and traditional Chinese medicine.