Study On The Relationship Between Serum Complement C1q Level And Coronary Heart Disease

Objective Myocardial cell ischemia and hypoxia is the main cause of myocardial injury and even necrosis,and the negative effect of inflammatory reaction on myocardial injury is also very common.By studying the serum complement C1 q of coronary heart disease patients and normal people,the expression of serum complement C1 q in the serum of patients with coronary heart disease was discussed.Methods This study was mainly included in the period from December 2017 to December2018,135 patients with coronary heart disease who were diagnosed in Jiangsu Subei people's hospital with chest distress and chest pain as the main complaint,including 35 patients with acute myocardial infarction,53 patients with unstable angina pectoris and47 patients with stable angina pectoris.The age,gender,BMI,past history,blood biochemistry,color doppler echocardiography and other information were recorded in detail.In the acute myocardial infarction group,blood biochemistry and bedside echocardiography were collected three times at 24 hours,4 days and 7 days after chest pain.Patients discharged from the hospital with acute coronary syndrome were followed up for three months,and clinical data with and without MACE events were recorded.Using T test and chi-square test,single factor variance analysis and related statistical methods,the serum complement C1 q changes in coronary heart disease(CHD)patients and normal physical examination in the serum level,serum complement C1 q with cumulative number of coronary heart disease in patients with coronary artery disease,serum complement C1 q changes in acute myocardial infarction patients,serum complement C1 q and coronary heart disease(CHD)MACE correlation research on the relationship between the incident.Results There were significant differences in age,female proportion,smoking proportion,hypertension,fasting blood glucose,high density lipoprotein,serum creatinine,AST,complement C1 q,CRP,WBC and ejection fraction between the patients with acute coronary syndrome and stable angina pectoris and the control group(P < 0.05,P < 0.01).There was no statistical significance in the proportion of diabetes mellitus,BMI index,TG,LDL,LPA,ALT(P > 0.05).The level of serum C1 q in the control group was lower than that in the CHD group,and the difference between the two groups was statistically significant(P < 0.05).The difference between C1 q in the acute coronary syndrome group and that in the stable angina group was statistically significant(P < 0.05).The level of complement C1 q was the highest in the acute coronary syndrome group,followed by the stable angina group,and the lowest in the control group.Serum complement C1 q was correlated with the cumulative number of coronary artery disease in patients with coronary heart disease.Serum complement C1 q was statistically significant(212.17 ± 24.63vs241.02 ± 33.09vs273.56 ± 35.28,P = 0.028)in patients with single vessel disease,double vessel disease and multi vessel disease.The difference of serum complement C1 q between patients with mace and those without mace was statistically significant.Conclusion Compared with the healthy controls,the level of serum C1 q in CHD patients was significantly increased,and the level of serum C1 q in CHD patients increased first and then decreased dynamically when AMI occurred,suggesting transient immune response and complement system activation in AMI patients;For patients with CHD,serum C1 q can assist in determining the severity of coronary artery lesions by coronary angiography.Detection of serum complement C1 q in patients with ACS has certain predictive value for the occurrence of MACE events.