Relative Study Of Serum 25(OH) D Levels And Its Correlation With The SYNTAX Scores Of Coronary Artery Stenosis In Patients With Coronary Heart Disease

Aim:To investigate the serum levels of 25(OH) D and analyze its relationship with the severity of coronary artery stenosis in patients with coronary heart disease.Methods:150 patients underwent coronary angiography, record all selected objects in general, including gender, age, height, weight, history of hypertension and diabetes and so on. Biochemical parameters were measured by immune nephelometry dialysis, including fasting glucose, total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), serum calcium(Ca2+). The serum 25(OH) D levels were measured by high performance liquid chromatography-tandem mass spectrometry in all patients. They were divided into normal control group and coronary artery lesion group according to the angiography results. The coronary artery lesion group was divided into mild、moderate and severe subgroups according to SYNTAX score.Results:1. The serum 25(OH) D levels was(14.11±6.94) ng/ml in patients with coronary heart disease and(21.51±7.16) ng/ml in normal control group. The serum 25(OH) D levels in patients with coronary was lower than that of control group(P<0.05),and gradually decreased as the severity of coronary artery lesions became more severe(P<0.05). 2. The serum 25(OH) D levels of selected males and females was(20.41±7.38)ng/ml and(21.98±8.24)ng/ml, and there is no significant difference between the two(p = 0.583). 3.In SYNTAX scores ≥33 group、SYNTAX scores 23~32 group and SYNTAX scores ≤22 group the serum 25(OH) D levels were(7.57±2.18)ng/ml、(11.39±4.24)ng/ml and(14.85±7.09) ng/ml. they were significantly lower than that of control group(P <0. 05). With the increase of SYNTAX scores, The serum 25(OH) D levels decreased obviously(P<0.05). There was a negative correlation between the serum 25(OH) D levels and the coronary artery lesions STNTAX scores(r=-0.328,p=0.019).4. The levels of TC、TG、HDL-C、 LDL- C, blood sugar 、body mass index and serum calcium was(4.32±1.06)mmol/L 、(1.75±0.41)mmol/L 、(1.96±0.51)mmol/L 、(2.85±0.98)mmol/L、(5.81±1.37)mmol/L、(24.21±2.34) kg/㎡ and(2.16±0.18)mmol/L. Bivariate correlation analysis of 25(OH) D level with the age, LDL- C, body mass index, blood sugar and serum calcium revealed no obvious correlation. 5. Logistic regression analysis showed that serum 25(OH) D(OR = 2.245, p <0.01) as independent factors of coronary artery disease.Conclusion:1. The serum 25(OH) D levels decrease significantly in patients with coronary heart disease, and its level is negatively related to the degree of coronary artery lesions. 2. The levels of the serum 25(OH) D and body mass index, low density lipoprotein, high blood pressure, blood glucose, calcium has no significant correlation. 3. Serum 25(OH) D is an independent risk factor for coronary heart disease in patients with coronary artery disease impact. This reveals the serum 25(OH) D plays a synergistic effect in the development of coronary atherosclerosis.