| Background At present,the prevalence rate of alcohol dependence is increasing year by year,while the effective treatment drugs are few,the re-drinking rate is high,and the complications are many,which not only affect the patients' quality of life,but also lead to huge economic losses.Studies have shown that physical therapy,especially High frequency-repetitive Transcranial Magnetic Stimulation(HF-r TMS),has a certain effect on addictive behavior.Currently,most of the research on the treatment of patients with addiction focuses on the dorsolateral prefrontal cortex.There are many studies on the treatment of r TMS at home and abroad,but the results for the treatment of alcohol dependence are different.Objective 1.Understand the correlation between drinking and cognitive impairment.2.To explore the effect of HF-r TMS on alcohol dependence craving,cognitive impairment and delayed emotional disorder.Methods Sixty-four male alcohol-dependent patients admitted to Henan Psychiatric Hospital from march to July 2019 were asked to stop drinking for at least two weeks.In this study,the eligible patients were numbered according to the principle of randomization,and were divided into the study group and the control group according to the random number table method.The control group was given sertramine at 50mg/ day after the acute withdrawal period to improve the drinking situation and emotional problems of the alcohol-dependent patients,and other routine abstinence treatment was given at the same time.The study group was additionally treated with HF-r TMS.The visual analogue craving scale,the Hamilton anxiety and depression scale,and cognitive function were assessed before and after the administration of sertrillin,including Mini Mental State Examination,Digit Span Test,Verbal Fluency Test,and Hopkins Verbal Learning Test Revised.Results 1.There was no statistically significant difference between the two groups in age before treatment,years of education,age of first drinking,cumulative use time and daily consumption of drinking(P > 0.05).2.There was no statistically significant difference between the pre-treatment visual analogue craving scale,Hamilton anxiety scale,Hamilton depression scale,Mini Mental State Examination,Digit Span Test,Verbal Fluency Test,and Hopkins Verbal Learning Test Revised between the two groups(P > 0.05).3.The visual analogue craving scale,Hamilton anxiety scale,Hamilton depression scale,Mini Mental State Examination,Digit Span Test,Verbal Fluency Test,and Hopkins Verbal Learning Test Revised in the study group before and after treatment all improved,with statistically significant differences(P < 0.01).4.The visual analogue craving scale,Hamilton anxiety scale,Hamilton depression scale,Mini Mental State Examination,Digit Span Test,Verbal Fluency Test,and Hopkins Verbal Learning Test Revised in the control group before and after treatment were also improved,with statistically significant differences(P < 0.01).5.Two groups of patients before and after treatment the neuropsychological test difference comparison: visual simulation for the group scale,Hamilton anxiety scale and Hamilton depression scale,Mini Mental State Examination,Digit Span Test,Verbal Fluency Test,and Hopkins Verbal Learning Test Revised is higher than control group,and the difference is statistically significant(P < 0.05).6.The person correlation analysis results of neuropsychological tests and drinking characteristics of patients in the two groups before treatment showed that the cumulative use time of patients with alcohol dependence was negative with Hopkins Verbal Learning Test Revised(r =-0.320,P = 0.010),and no other statistical correlation was found(P > 0.05).Conclusions 1.Both groups reduced cravings and improved mood and cognitive function in alcohol-dependent patients,but High frequency-repeated transcranial magnetic stimulation was more effective.2.The cumulative drinking time of alcohol dependence was negatively correlated with Hopkins word learning. |
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