| Objective: To evaluate low frequency repetitive transcranial magnetic stimulation combined with duloxetine on serum BDNF level and cognitive function to treat patients with senile depression.Methods: 60 patients treated in the mental health center of Qingdao in Shandong during December 2016 to August 2017 with senile depression were selected and randomly divided into RS group(Real stimulation group)(n = 30)treated with r TMS combined with duloxetine and PS group(Pseudo stimulus group)(n= 30)treated with sham stimulus combined with duloxetine.The r TMS stimulation of two groups were 80%MT,the stimulation frequency was 1Hz,a series of stimulation is 100 consecutive times,five consecutive days is one treatment courses,and treat the patients for 8 weeks.Before treatment and 8 weeks after treatment,they were assessed with Hamilton Depression Scale(HAMD-17)to evaluate depressed emotions and Repeatable Battery for the Assessment of Neuropsychological Status(RBANS)for cognitive function.serum BDNF levels were assayed by ELISA in the second day of hospitalization and 8 weeks after treatment.Results: 1.There was no significantly difference between the basic data including sex composition,age and course of disease in the two groups of senile depressive disorder(p>0.05).2.After treatment for 8 weeks,the HAMD-17 scores were significantly lower than that before treatment in two groups.The BDNF level and RBANS scores in 8 weeks after treatment were significantly higher than that before treatment(P<0.05).3.Compared with control group,the HAMD-17 scores were significantly reduced,the BDNF level were significantly increased in the study group(P<0.05).There was no significant difference of speech function between 2 groups(p>0.05),but the other indexes of RBANS were significantly higher than those in the control group(P<0.05).Conclusion: 1.Low frequency repetitive transcranial magnetic stimulation combined with drug therapy may be a more effective treatment for patients with senile depressive disorder.2.Low frequency repetitive transcranial magnetic stimulation combined with drug therapy can improve the cognitive function of elderly patients with depressive disorder.3.Low frequency repetitive transcranial magnetic stimulation can improve the cognitive function of the patient,but it may have no advantage in improving the language function.4.Low frequency repetitive transcranial magnetic stimulation can effectively improve the level of serum brain neurotrophic factor in elderly patients with depressive disorderMeaning: the elderly patients with depression in drug treatment adding by low frequency repetitive transcranial magnetic stimulation can improve the patient's depressive symptoms,can increase the brain neurotrophic factor,also can improve the cognitive function of patients,can better keep the patient's social function,is conducive to the comprehensive rehabilitation of patients. |
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