Effect Of Olanzapine Combined With Tandospirone On Efficacyand Cognitive Function In Schizophrenia Patients

Background Schizophrenia is a group of severe mental disorders with unknown causes.Cognitive dysfunction persists for a long time,which seriously affects the recovery of patients social function.No drugs have been found to have a significant effect on cognitive improvement.Some studies have shown that 5-HT₁A receptor agonists improve the cognitive function of schizophrenia,with Tandospirone acting as a partial agonist for 5-HT₁A receptors,Studies have also shown that it promotes the release of dopamine in the cerebral cortex and hippocampus and improves negative symptoms in patients,improving the cognitive function of patients.the aim of this study was to investigate the clinical efficacy of tandospirone combined with olanzapine in patients with schizophrenia and the effects on cognitive function.Objectives 1.To investigate the changes of mental symptoms after combined treatment with tandospirone.2.To investigate the changes of cognitive function after combined treatment with tandospirone.3.To explore the difference of the safety indexes of liver function,blood routine and extrapyramidal reaction after combined treatment with tandospirone.Methods 1.Inthis study used a randomized controlled study to collect a total of 79 schiz ophrenia patients who met the diagnosed criteria of the international statistical classi fication of diseases and related health problems?International Statistical Classificati on of Diseases and Related Health Problems,ICD-10?.patients were randomly assi gned to the tandospirone combined with olanzapine treatment group?study group?a nd placebo combined with olanzapine treatment group?control group?for 8 weeks.A total of 70 patients with schizophrenia,including 39 in the study group,26 in m en,2 in abscission,13 in women,2 in the control group,40 in men,25 in men,3 in women,15 in women,2 in abscission,were all lost after discharge.2.The basic clinical data of all subjects were collected,and the age,education and course of disease of the two groups were collected respectively.the two groups were evaluated for positive and negative symptoms scale?PANSS?at baseline,trea tment 4 weekend,treatment 8 weekend,Trail Making Test,Symbolic coding,Categ ory Fluency-Animal Naming Fluency,Continuous Performance Test-Identical Pairs,W echsler Memory Scale-?Spatial Span,Hopkins Verbal Learning Test-Revised,Brief Visuospatial Memory Test-Revised,neuropsychological assessment battery-mazes,an d mayer-salovey-caruso emotional intelligence test at1weekend,and 8 weekend after treatmentand Treatment Emergent Symptom Scale?TESS?at 2 weekend,4 weeken d,8 weekend after treatment.3.Apply SPSS 21.0 Statistical software analysis of data,counting data using?² test or Fisher exact probability method,measurement data using two factors repeated measurement variance analysis,group comparison using independent sample test,group using paired sample t test.Bilateral P<0.05 was statistically significant.Measurement data are expressed as mean±standard deviation????±s?.Results 1.There was no significant difference in sex,age,course and education between the two groups?P>0.05?.At baseline,there was no significant difference in the scores of cognitive function assessment and positive,negative,total and general pathological symptoms in the study group and the control group?P>0.05?.2.After 8 weeks of treatment,there was no significant difference in general psychiatric symptoms between the study group and the control group?P>0.05?,The difference in positive symptoms,negative symptoms and total score between the study group and the control group was statistically significant?P>0.05?.For 8 weekends of treatment,after repeated measurement analysis of variance comparison,the results showed that the difference between the study group and the control group was statistically significant in was statistically significant?P>0.05?.3.After 8 weeks of treatment,the difference between the study group and the control group was statistically significant in connection,word learning and maze?P<0.001?.There was no significant difference in symbol coding,spatial breadth,fluency,visual memory,emotion management and continuous operation between the two groups?P>0.05?.After 8 weeks of treatment,The differences in connection,symbol coding,word learning,maze and range fluency before and after treatment in the study group were statistically significant?P>0.05?,while the difference in continuous operation before and after treatment in the control group was statistically significant?P>0.05?.There was no significant difference in spatial breadth and emotional management between the study group and the control group before and after treatment?P>0.05?.4.After 8 weeks of treatment,the study group and the control group showed no significant difference in insomnia,blood routine,liver function,extrapyramidal reaction,ECG,constipation,diarrhea,headache and so on?P>0.05?,The difference in body weight between the two groups was statistically significant?P>0.05?,The study group lost more weight than the control group.Conclusions 1.Tandospirone can improve cognitive function in patients with schizophrenia.2.Tandospirone was effective for the negative symptoms of schizophrenia patients,and had no obvious effect on the positive symptoms,general pathological symptoms and total score.3.Tandospirone has less adverse reactions and safety in schizophrenia patients.