| Objective:Under the guidance of basic theories of traditional Chinese medicine,the clinical efficacy and safety of Ultrafine Granular Powder of Salvia Miltiorrhizae Chuanxiong Gastrodiaelata Combined with Nifedipine Controlled-release Tablets in the treatment of syndrome of ascendant hyperactivity of liver yang and syndrome of static blood blocking orifices were observed.Method:76 patients who met the requirements of the outpatient department or inpatient department of the Cardiology Department of Wuhan Hospital Of Traditional Chinese And Western Medicine from 2018.10.1 to 2019.5.1 were selected,and the patients were selected to meet the diagnosis of primary hypertension and the TCM syndrome differentiation It is in accordance with the syndrome of liver yang hyperactivity and blood stasis resistance.76 patients were arranged in order of admission,and then divided into a research group and a control group according to the random number table,including 37 cases in the study group and 39 cases in the control group.The control group was given oral Nifedipine controlled-release tablets(Baixintong)30 mg once a day;the study group combined with Ultrafine Granular Powder of Salvia Miltiorrhizae Chuanxiong Gastrodiaelata(Ultrafine Granular Powder of Salvia Miltiorrhizae,Ultrafine Granular Powder of Chuanxiong,Ultrafine Granular Powder of Gastrodiaelata,a bag of each drug was mixed together)take drenched,twice a day.After 12 weeks of treatment,compare the TCM symptom scores of the two groups of subjects before and after treatment;compare the blood pressure levels of the two groups of patients before and after treatment(take the average of three measurements)and the 24-hour ambulatory blood pressure results,and compare the blood pressure reduction effects of the two groups;record two The changes of echocardiogram before and after treatment in the two groups were compared,and the end-diastolic septal thickness of the two groups before and after treatment was compared,and the effect of delaying the interventricular thickening at the end of diastole was analyzed;the levels of C-reactive protein(CRP)before and after treatment in the two groups were compared;Electrolyte,myocardial enzyme spectrum and blood lipid levels before and after treatment in the group;fasting blood glucose,liver and kidney function and electrocardiogram of the two groups before and after treatment were monitored for safety analysis.The data obtained in this experiment were measured using mean ±standard deviation(`x±s).Comparison between groups was performed by t test,p<0.05 was considered statistically significant,and all the collected data above were processed by SPSS 22.0 statistical analysis.Result:1.In terms of improving the TCM symptoms of patients: the TCM symptom scores of patients in the control group and the study group were significantly lower after treatment than before treatment,and the study group was superior to the control group after treatment(p<0.05),with statistically significant differences.The total effective rate of TCM symptom improvement was 86.49%in the study group,which was higher than 64.10% in the control group.The difference between the two groups was statistically significant(p<0.05).2.In terms of blood pressure control:As for the comparison of blood pressure levels,the control group was significantly lower than before treatment(p<0.05),and the study group was significantly lower than before treatment(p<0.05).Both groups were more effective in reducing SBP.DBP reduction was significant,and the antihypertensive effect of the study group was better than that of the control group(p<0.05),and the difference was statistically significant.As for the comparison of the effectiveness of the antihypertensive effect,the total effective rate of the research group was 94.59%,which was higher than that of the control group.87.18% high(p<0.05),the difference is statistically significant.3.Effects of interventricular septum interventricular septum thickness,respectively,the two groups after treatment than before treatment reduced(p<0.05),ventricular septal thickness comparison after treatment,the control group and the team there was no statistically significant difference(p>0.05),the results show that in the control group and the team could be reversed ventricular septal thickening,there was no statistically significant difference effect of two groups of treatment.4.Comparison of blood lipid and serum CRP results:As for the comparison of blood lipids TG,HDL-C,and LDL-C,the effect of the two groups on blood lipids was not statistically significant(p>0.05);for comparison of serum CRP,compared with the control group The study group can effectively reduce serum CRP levels(p<0.05),and the difference is statistically significant;5.Comparison of electrolyte and myocardial enzyme spectrum results:for the comparison of serum sodium,serum potassium,CK,CK-MB,LDH and α-HBDH,there was no statistically significant difference in the effects of serum sodium,serum potassium,CK,CK-MB,LDH and α-HBDH between the two groups before and after treatment(p>0.05).6.During the treatment,no allergic reactions,adverse reactions or abnormalities in various laboratory tests and examinations were found in the two groups.Conclusion:Ultrafine Granular Powder of Salvia Miltiorrhizae Chuanxiong Gastrodiaelata Combined with Nifedipine Controlled-release Tablets,can effectively alleviate the liver Yang syndrone,obsessed with the blood stasis resistance type hypertension patients’ clinical symptoms and improve TCM symptoms integral,lower blood pressure,reduce serum CRP level,to achieve effective treatment of liver Yang syndrone,obsessed with the blood stasis resistance type hypertension,the purpose of,and does not increase adverse reactions. |
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