Clinical Observation Of Jianpi Huanji Prescription In Treating Diarrhea-predominant Irritable Bowel Syndrome(Spleen Deficiency And Dampness Excess Syndrome)

Objective:The study is used to observe the clinical effects of Jianpi Huanji Prescription in treating diarrhea-predominant irritable bowel syndrome(spleen deficiency and dampness excess syndrome)and to provide a basis for better clinical application of Jianpi Huanji PrescriptionMethods:The object of this research included outpatients and inpatients of spleen and stomach disease department in Changzhou TCM Hospital from January 2019 to December 2019,who were 18 to 60 years old and were diagnosed as diarrhea-predominant irritable bowel syndrome(spleen deficiency and dampness excess syndrome).According to the method of random number table,they were divided into treatment group and control group,thirty cases in each group.The patients in treatment group were treated with basic treatment+Jianpi Huanji Prescription and the patients in control group were treated with basic treatment+Compound Glutamin entersoluble capsules+Compound Lactobacillus acidophilus tablets.The course of treatment was four weeks.The observations were the changes of TCM syndrome integrals before treatment,after four weeks of treatment and after one month of drug withdrawal and the changes of electroenterogram data before and after treatment in two groups.All of the data were statistically analyzed to evaluate Jianpi HuanJi Prescription's therapeutic efficacy and its long-term efficacy.Before and after the treatment,vital signs,three major routine,liver and kidney function test,electrocardiogram manifestations and untoward effect of the two groups of patients were observed to evaluate Jianpi Huanji Prescription's safetyResults1.A total of sixty patients were included in this research,fifty-seven patients actually completed the entire treatment and observation process.In the treatment group,twenty-nine patients completed the whole treatment and observation process,and one patient dropped out.In the control group,twenty-eight patients completed the whole treatment and observation process,and two patients dropped out.The drop-out rate was 5%2.Total integrals of TCM syndrome:The total integrals of TCM syndrome in the two groups after treatment were lower than those before treatment(P<0.01);The comparison between the two groups after treatment showed that the treatment group was significantly better than the control group in improving TCM syndrome(P<0.01).3.Single TCM symptom:After four weeks of treatment,the TCM symptoms of the two groups were significantly improved comparing with those before treatment(P<0.05).In comparison between the two groups,the effect of the treatment group on improving the TCM symptoms like sloppy diarrhea and abdominal pain was similar to that of the control group(P>0.05),while the effect of the treatment group on improving other symptoms like onset or aggravation after fatigue,onset or aggravation after catching cold,mental fatigue and loss of appetite was better than that of the control group(P<0.05)4.TCM syndrome effect:After four weeks of continuous treatment,the total effective rate was 90%in the treatment group and 79%in the control group.The treatment group was better than the control group in the comparison of TCM syndrome effect(P<0.05).5.Electroenterogram data:After four weeks of continuous treatment,the waveform average frequency and the percentage of disorder of enteroelectricity rhythm of each lead of electroenterogram in the treatment group and the control group were lower than those before treatment(P<0.01).The waveform average frequency reflects the speed of enteroelectricity rhythm and the percentage of disorder of enteroelectricity rhythm reflects the disorder of enteroelectricity rhythm,it showed that the treatment of two groups could regulate the patients' enteroelectricity rhythm and improve the disorder of enteroelectricity rhythm.The effect of the treatment group was more obvious than that of the control group in regulating the enteroelectricity rhythm of the descending colon and rectum and improving the disorder of the enteroelectricity rhythm of the descending colon(P<0.05),while the effect of the treatment group was similar to that of the control group in regulating the enteroelectricity rhythm of the ascending colon and improving the disorder of the enteroelectricity rhythm of the ascending colon and rectum(P>0.05).6.Recurrence:After one month of drug withdrawal,the recurrence rate of the treatment group was 12%,and that of the control group was 41%.The recurrence rate of the treatment group was lower than that of the control group(P<0.05).7.Safety:Before and after treatment,all safety indexes of the two groups of patients were not changed abnormally,and no adverse drug reactions occurred during the study period,indicating that both groups of drugs were safe.Conclusion:The therapeutic effect of Jianpi Huanji Prescription on diarrhea-predominant irritable bowel syndrome(spleen deficiency and dampness excess syndrome)is significant.Jianpi Huanji Prescription can obviously improve the patients' various discomfort symptoms,regulate the enteroelectricity rhythm,improve the disorder of the enteroelectricity rhythm,and it has a certain long-term effect.At the same time,it has no obvious adverse reaction.So Jianpi Huanji Prescription is worthy of widely clinical application.