Clinical Observation On The Clinical Effect Of Chaiqi Mixture In The Treatment Of QiDeficiency And Blood Stasis In The Convalescence Of Cerebral Infarction

Objective:To observe the effect of Chaiqi mixture on clinical neurological deficit score,activity index of daily living,plasma D-dimer level,sublingual vein and TCM symptom scores in patients with qi deficiency and blood stasis syndrome during cerebral infarction recovery.Evaluate effective and safety.Methods:From xiamen university affiliated hospital of sun yat-sen regions ward and xiamen traditional Chinese acupuncture,encephalopathy ward into the group operator cerebral infarction convalescence diagnosis standard and conform to the stroke patients with qi deficiency blood stasis syndrome diagnostic criteria of 106 cases,A 1:1 randomized control table was used to randomly divide the 106 patients who met the standard into 53 patients in the control group(naoxintong capsule group)and 53 patients in the experimental group(chai qi mixture group).Both groups were given basic treatment(conventional drug treatment + rehabilitation treatment).The control group was given an oral naoxintong capsule,once 2-4 capsules,three times a day,In the treatment group,chaiqi mixture was given(15g of chaihu,20g of dilong,50g of huangqi,15g of shichangpu,15g of chishao,20g of foshou).One dose per day,decocted in water to 200ml,and taken warm twice after meals in the morning and evening.The treatment courses were all 4 weeks.Before and 4 weeks after treatment,patients were tested for clinical neurological deficit(NIHSS score),daily living activity ability(ADL score),plasma d-dimer level and safety indicators,and sublingual ventral tortuosity and TCM syndromes of the two groups were observed and recorded.Statistical analysis was performed using statistical software to compare the differences in NIHSS score,ADL score,plasma d-dimer level,sublingual vein and TCM syndrome score between the two groups before and after treatment.Adverse reactions during the treatment were also recorded.Blood,urine,feces,liver,kidney function,ecg as safety evaluation indicators.Results:1.After sample size estimation,the total in 106 cases of patients,fall off 6 cases,100 cases of actual finish falls off at a rate of 5.6%.2.Before the treatment,two groups of patients the NIHSS score,ADL scores,plasma D-dimer level,the sublingual veins and TCM symptom score comparison differences had no statistical significance(P>0.05).3.After 4 weeks of treatment,both NIHSS scores were reduced(P<0.05),and the comparison between the groups was more evident than the NIHSS score of the control group of the test group.The difference was statistically significant(P<0.05).4.After 4 weeks of treatment,ADL scores of both groups were improved compared with those before treatment(P<0.05).Compared between groups,the ADL score of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).5.After 4 weeks of treatment,plasma d-dimer level in both groups was lower than that before treatment(P<0.01).Plasma d-dimer level was similar between the two groups,and the difference was not statistically significant(P>0.05).6.After 4 weeks of treatment,both groups showed improvement in sublingual venous tortuosity(P<0.05).Comparison between the two groups showed that the sublingual ventral tortuosity was similar between the two groups,and the difference was not statistically significant(P>0.05).7.After 4 weeks of treatment,the TCM symptom score of the two groups of patients decreased compared with that before treatment(P<0.05).Compared with the control group,the TCM symptom score of the experimental group decreased significantly compared with that of the control group,and the difference was statistically significant(P<0.05).8.The total effective rate of clinical neurological function in the experimental group was 90%,and that in the control group was 84%.The experimental group was superior to the control group(P<0.05).The treatment group was superior to the control group in the efficacy of daily living activities;the experimental group TCM syndrome The total effective rate was 92%,and the control group was 86%.The test group was superior to the control group(P<0.05).9.During the treatment,the patient's general vital signs were monitored,and the three major routines,liver and kidney function and ecg of the patient were checked once before and after the treatment,without any abnormal changes.No serious adverse reactions were found in both groupsConclusion:1.Both chaiqi mixture and naoxintong capsule can reduce the NIHSS score and plasma d-dimer level of patients,improve the ADL score of patients,and improve the sublingual ventral tortuosity of patients.However,chai qi mixture was more obvious in reducing NIHSS score and improving ADL score of patients than naoxintong capsules,and there was no significant difference in reducing plasma d-dimer and improving sublingual vein.2.Chaiqi mixture has significantly improved the TCM syndromes of patients with qi deficiency and blood stasis accompanied by depression during the convalescence of cerebral infarction compared with that of naoxintong capsule.3.Chaiqi mixture is safe and effective in the clinical application of treating qi deficiency and blood stasis with depression in the convalescence of cerebral infarction.