Analysis Of Survival And Prognosis Of Patients With Leukocyte And Malignant Tumor

Objective:The purpose of this study is to investigate the relationship between peripheral white blood cell count and survival and prognosis of453 patients with malignant tumor before treatment.Methods:The clinicopathological data of 453 patients with malignant tumor were collected,including 90 patients with hepatocellular carcinoma,199 patients with lung cancer,60 patients with laryngeal phosphorus cancer,and 104 patients with ovarian cancer.As well as date from 79 normal healthy subjects were gathered.The differences of peripheral blood leukocyte between healthy people and malignant tumor patients before treatment were analyzed retrospectively.The chi-square test was used to compare the clinicopathological data between the groups,with the median of the differentiated leukocytes as the boundary value.Kaplan-meier univariate survival analysis and log-rank test were adopted to analyze the survival of patients with different malignant tumors.For univariate analysis,statistically significant factors(P < 0.05)were analyzed,and Cox multivariate regression model was employed to determine independent factors affecting the prognosis of patients with malignant tumors.Results:1.The peripheral blood neutrophil/lymphocyte ratio of the selected patients with liver cancer,lung cancer,laryngeal cancer and ovarian cancer was significantly higher than that of the healthy control group,and the difference was statistically significant(P < 0.05).2.The difference of neutrophil/lymphocyte ratio(NLR)between liver cancer and hypersplenism was statistically significant.The difference of NLR betweenlung cancer,laryngeal cancer and ovarian cancer was statistically significant.3.Kaplan-meier analysis showed no significant correlation between WBC count and survival prognosis of patients with 4 types of malignant tumors,but the ratio of neutrophil to lymphocyte was correlated with survival prognosis of patients with tumor,and the survival time of patients with 4 types of malignant tumors in the high NLR group was shorter than that in the low NLR group(P < 0.05).4.Results of univariate analysis: NLR,vascular invasion,T stage,lymphatic metastasis,tumor diameter,and chemotherapy were all factors affecting survival of liver cancer patients(P<0.05).Smoking,staging,radiotherapy and chemotherapy,and the ratio of neutrophils to lymphocytes were the survival factors of patients with lung cancer(P < 0.05).Tumor stage and NLR were the factors affecting survival of laryngeal cancer patients.Tumor stage,surgical treatment and the ratio of neutrophils to lymphocytes were the factors affecting survival of ovarian cancer patients.COX multivariate analysis showed that portal infiltration,lymphatic metastasis and NLR were independent factors affecting the survival and prognosis of liver cancer patients.Smoking,tumor stage and chemotherapy were independent factors affecting the prognosis of lung cancer patients.Tumor staging and NLR were independent prognostic factors for laryngeal cancer patients.Tumor staging and surgical treatment were independent prognostic factors for ovarian cancer patients.Conclusion:There was no significant correlation between WBC count and survival of liver cancer,lung cancer,laryngeal cancer and ovarian cancer.Neutrophil/lymphocyte ratio is associated with the survival and prognosis of 4 types of malignant tumors,and it is an independent risk factor affecting patients with liver cancer and laryngeal cancer,which may have certain clinical value for the prognosis evaluation of patients with malignant tumors.