| ObjectiveThe main purpose of this study was to compare the clinical efficacy of spleen-deficiency and damp-heat type androgenetie alopecia by scouring scalpwith compound platycladus orientalis solution and 5%minoxidil tincture,toconfirm the efficacy and safety of compound Oriental Arborvitae solution external washing in the treatment of androgen alopecia due to spleen deficiency and dampness-heat.MethousThe patients with spleen deficiency and dampness-heat alopecia of the dermatology clinic of Shenzhen Hospital of Traditional Chinese Medicine from May 2018 to August 2018 were selected as patients.And then 60 patients were divided into control group and experience group by random number grouping method,30 cases in each group.Informed consent was required for both groups of patients at the time of enrollment.The two groups of common basic treatments are oral administration of our hospital prescription Jianpi Qushi granules,and suggestions for adjustment of lifestyle.In the experimental group,the basal treatment plan was supplemented with compound platycladus orientalis solution to wash the scalp,and the control group was coated with 5%minoxidil tincture in the basic treatment.The study was treated for 8 weeks.The changes of hair loss score,scalp itch score(VAS),scalp greasy score,scalp pityriasis score,grow again hair score and dermatological quality of life score(DLQI)were compared before and after treatment.And observed the safety of treatment,collated the relevant data,and made statistical analysis.Result(1)In this study,patients' treatment and follow-up compliance were good,and no cases were lost.A total of 60 cases were completed.(2)Compared with general data,there was no significant difference in sex ratio between the experience group and the control group(P>0.05),and there was no significant difference in age and course of disease between the two groups(P>0.05)·(3)Compared with curative effect index,after treatment,the totalclinical effective rate was 93.3%in the experience group and 73.3%in the control group.There was a significant difference between the two groups(P<0.05).(4)Comparison of hair loss scores between the two groups before and after treatment:There was a significant difference in hair loss scores between different time points(P<0.0001),that is,the symptoms of hair loss were significantly improved in the two groups after 4 weeks and 8 weeks of treatment;there was no significant difference in grouping and time interaction(P>0.05).There was no significant difference in the scores of hair loss between the two groups at 8 weeks of treatment(P>0.05),indicating that there was no difference in the efficacy of the two groups in improving the symptoms of alopecia.(5)Comparison of scalp pruritus scores before and after treatment in the two groups:There was no significant difference in scalp pruritus between the two groups before treatment(P>0.05),which was comparable.There was a significant difference in grouping and time interaction(P<0.05),suggesting that the experimental group was superior to the control group in improving the symptoms of scalp pruritus.There were significant differences in scalp pruritus scores at different time points(P<0.01),suggesting that bothtreatments can effectively improve the symptoms of scalp pruritus;after 4 and 8 weeks of treatment,the scalp pruritus scores of the experimental group were significantly different from those of the control group(P<0.05),suggesting that the experimental group is better than the control group.(6)Comparison of scalp greasy scores before and after treatment in both groups:There was no significant difference in scalp greasy score between the two groups before treatment(P>0.05),which was comparable.There weresignificant differences in scalp greasy scores at different times(P<0.0001).suggesting that both treatments significantly improved scalp greasy symptoms at 4 and 8 weeks of treatment;group and time interactions were significantly different(P<0.01)and After 8 weeks of treatment,there was a significant difference between the experimental group and the control group(P<0.05),suggesting that the experimental group was better than the control group in improving the scalp greasy symptoms.(7)Comparison of scalp rashes before and after treatment in both groups:There was no significant difference between the two groups before treatment(P>0.05),which was comparable.There were significant differences in scalp pityriasis scores at different time points(P<0.0001),suggesting that both treatments significantly improved the symptoms of scalp pityriasis at 4 and 8 weeks of treatment;there was a significant difference in grouping and time interaction(P<0.0001),there was a significant difference between the experimental group and the control group at 4 and 8 weeks of treatment(P<0.01),suggesting that the experimental group was better than the control group.·(8)Comparison of regenerative hair scores after 4 weeks and 8 weeks aftertreatment in both groups:There was a significant difference between the two groups after 8 weeks of treatment and 4 weeks after treatment(P<0.05),suggesting that both treatments can effectively promote hair growth;after 4 weeks and 8 weeks,between the two groups There was no significant difference in the scores(P>0.05),suggesting that there was no significant differencee-in the efficacy of promoting hair growth between the two groups.(9)Comparison of DLQI scores before and after treatment in both groups:There was no significant difference in the score before treatment(P>0.05),which was comparable.The DLQI scores were significantly different at different time points(P<0.01),which proved that both treatments can effectively improve the quality of life of patients.There was a significant difference in grouping and time interaction(P<0.01),and there was a significant difference between the two groups after 8 weeks of treatment(P<0.05),suggesting that the experimental group was better than the control group in improving patients' quality of life.ConclusionThe external compound arborvitae solution has achieved good clinical results in patients with spleen-deficiency and damp-heat type androgenetic alopecia,and the total effective rate is better than the control group;it can effectively control hair loss and promote hair regeneration,and improve scalp greasy,itching and scalp sputum The symptoms of rash and improving the quality of life of patients are better than 5%minoxidil in external use,and there is no obvious adverse reaction,safe and effective. |
PDF Full Text Request