The Correlation Between Serum 25-hydroxyvitamin D And Allergic Rhinitis In Children

Objective:We attempt to investigate the correlation between serum 25-hydroxyvitamin D(25(OH)D)level and allergic rhinitis(AR)in children,in order to provide new clues for the pathogenesis of AR of children.Methods:76 AR children and 68 healthy controls aged 6 to14 from various counties and cities of Jiangxi Province were enrolled.All subjects recepted questionnaire survey,allergen skin prick test,serum specific IgE test,serum 25(OH)D test and routine blood test.AR children completed the Visual Analogue Scale(VAS)scores and Rhinoconjunctivitis quality of life questionnaire(RQLQ)scores.Result:1.The mean body mass index(BMI)of AR children was significantly lower than that of healthy peers(p <0.0001),but there was no correlation between BMI and serum 25(OH)D level.2.Serum 25(OH)D level of AR children was signtificantly lower,compared to the conrtols(p = 0.0008),while the area under the receiver operating characteristic curve(AUC)of subjects was 0.6614,That is,serum 25(OH)D was not an efficient auxiliary diagnosis in AR children.3.Serum 25(OH)D level of AR children was not correlated with the severity,gender,peripheral blood eosinophils and asthma.Conclusion:1.AR may affect the growth and development in children.2.Children's serum 25(OH)D deficiency was correlated to AR,but its efficiency for AR-auxiliary diagnosis is not high.So it cannot be used as an auxiliary indicator for clinical diagnosis of AR.3.Serum 25(OH)D deficiency may generally affect the body's immune function,but not specifically participate in the pathogenesis of AR.