| Research purposes:Allergic rhinitis is a chronic inflammatory disease of the nasal mucosa.As the incidence of allergic rhinitis in children is increasing,and it will have a certain impact on their life and study,it has attracted the attention of physicians and parents.This topic is aimed at children with allergic rhinitis of Benxubiaoshi type,and observing the clinical efficacy of Xuanfeijianpi Granules.At the same time,the children’s IgE antibody,eosinophil percentage,and high-sensitivity C-reactive protein were detected before and after treatment,and the possible mechanism of Xuanfeijianpi Granules was preliminarily explored,providing new ideas for clinical treatment of the disease.Research method:In this study,from September 2020 to February 2021,a total of 48 children were enrolled in the Pediatric Clinic of Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine.They were randomly divided into two groups,including 26 cases in the experimental group and 2 cases falling out(all were lost to follow-up),22 cases in the control group,1 case dropping out(lost to follow-up),and 45 cases were finally included,including 24 cases in the experimental group,and 21 cases in the control group.The test group was given Xuanfeijianpi Granules,and the control group was given Montelukast for a total of 3 weeks.The scores of TCM syndromes and VAS of the two groups before and after 1、2 and 3 weeks of treatment were counted.The IgE antibodies and EO%and hs-CRP levels of the treatment group were counted as well before and after treatment,in order to objectively evaluate the clinical efficacy and possible mechanism of Xuanfeijianpi Granules.Research result:1 Comparison of the total curative effect of the disease:the cure rate of the test group is 95.83%and the total effective rate 100%,which is higher than the cure rate of 4.76%in the control group,and the total effective rate 95.24%.The comparison of the effective rate of the two groups is not statistically different(P>0.05),which indicates that both have curative effects on the disease.The comparison of the two groups is statistically significant(P=0.000<0.01).The difference indicates that the cure efficacy of the experimental group is significantly better than that of the treatment group.2 Comparison of the scores of main symptoms of TCM syndromes:The P value of the scores of the main symptoms of the two groups after 1,2 and 3 weeks of treatment were all<0.01,indicating that the two groups have effects in improving the main symptoms.The scores of the main symptoms of the two groups were compared after 1,2 and 3 weeks of treatment.The P values were all<0.05,indicating that there were statistical differences in the efficacy of the main symptoms of the two groups.The efficacy of the experimental group was better than the control group.The experimental group had a good effect on the four main symptoms after 1,2 and 3 weeks,and time was proportional to curative effect.The control group had a certain effect on the symptoms of nasal congestion after 1 week of treatment;it had a certain effect on the other main symptoms after 1,2 and 3 weeks of treatment,and time was proportional to curative effect.Comparing the scores of the main symptoms between the two groups after treatment,the P values were all<0.01,indicating that the efficacy of the two groups was significantly different after the treatment.The efficacy of the experimental group was significantly better than that of the control group.3 Comparison of minor symptoms of TCM syndrome scores:The two groups were compared within the group.The total score of the test group’s P values was less than 0.01,indicating that the test group had an effect on the minor symptoms in three weeks,and time was proportional to curative effect;the control group’s P value of the total score of minor symptoms was<0.05 after 2 weeks,indicating this group had a certain effect after 2 weeks of treatment.After 1,2 and 3 weeks of treatment,the total scores of the minor symptoms were compared between the two groups.The P values were all<0.05,indicating that the efficacy of the minor symptoms of the two groups was statistically different during the treatment process,and the efficacy of the experimental group was better than the control group.After testing,the experimental group had curative effect on each symptom after 3 weeks of treatment.Except for the P value of emaciation before and after the treatment,the other P values were all<0.01,indicating that except for the symptoms of emaciation,Xuanfeijianpi Granules had obvious curative effect after 3 weeks of treatment.But it can also improve the symptoms of emaciation,it was not as obvious as the other symptoms.It had the fastest effect on the symptoms of anorexia,which can be improved within 1 week of treatment,and time was proportional to curative effect.For shortness of breath,fatigue and lientery were improved after 1 week of treatment,and time was proportional to curative effect;for spontaneous sweating,tongue condition,and pulse condition,there were effects after 2 weeks of treatment,and time was proportional to curative effect.The control group was compared within the group.Except for lientery and pulse condition improving after 3 weeks(P<0.05),there was no significant improvement before and after treatment(P>0.05),indicating that the effect of Montelukast for minor symptoms was not good.After 1,2 and 3 weeks of treatment for each symptom,the groups were compared,and it was found that the symptoms of anorexia,spontaneous sweating,fatigue,and lientery in the treatment group were better than the control group after 2 and 3 weeks;shortness of breath,the tongue and pulse conditions in the treatment group were better than that in the control group after 3 weeks.However,when comparing the scores of emaciation symptoms between groups,it was found that P=0.531>0.05,indicating that there was no significant difference in the efficacy of emaciation symptoms between the two groups.4 Analysis of visual analog scale for rhinitis:After 1,2 and 3 weeks of treatment of the two groups,P value was less than 0.01,indicating that the overall symptoms of the two.groups had improved after 1,2,and 3 weeks.The two groups were compared within groups,P=0.000<0.01,indicating that there was a significant statistical difference in the visual analog score of rhinitis between the two groups after 1,2,and 3 weeks of treatment.The efficacy of the experimental group was significantly better than that of the control group.5 Analysis of physical and chemical indicators:P values of IgE antibody and EO%in the experimental group before and after treatment were all<0.05,and the differences were statistically significant,indicating that Xuanfeijianpi Granules can effectively reduce the levels of the above indicators.Research conclusions:Xuanfeijianpi Granules have a definite effect in improving allergic rhinitis in children of Benxubiaoshi type,and the effect is significantly better than Montelukast.Especially in improving TCM syndromes,it reflects the advantages of TCM syndrome differentiation and treatment.After preliminary exploration,Xuanfeijianpi Granules may work by reducing the levels of IgE antibodies and EOS. |
