Investigation On The Correlation Between Olfactory Function And Tcm Syndrome Elements In Parkinson's Disease

Objective:(1)Observation of olfactory detection in PD diagnosis,and to explore possible influencing factors of olfactory dysfunction in PD patients.(2)To explore the distribution characteristics of syndromes and syndromes of dysosmia in PD patients,to explore the relationship between PD olfactory disorders and different syndromes,and to investigate the incidence of olfactory disorders in each TCM syndrome of PD.Methods:(1)According to the inclusion criteria and exclusion criteria,the subjects were divided into PD case group and control group.There were 66 cases and 54 cases in the two groups,and there was no significant difference in age and gender.The olfactory test was performed using the CCCRC olfactory test,and the olfactory function of the two groups was compared to investigate the incidence of PD olfactory disorder.The Hanmilton Depression Scale was used to assess the depression of the subjects;the severity of the PD patients was assessed using the Unified PD Rating Scale(UPDRS)Stages I to IV and the Parkinson's Disease Hoehn-Yahr(Amendment)Rating Scale.(2)According to the results of olfactory detection,the PD components were olfactory disorder group and non-olfactory disorder group,and cross-sectional study was performed.According to the PD TCM syndrome classification standard and the syndrome integral scale,the TCM syndrome types and syndromes of the patients were confirmed.The distribution patterns and syndrome distribution characteristics of olfactory disorder group and non-olfactory disorder group were compared.Results:(1)The results of the analysis showed that the olfactory threshold and recognition test scores of the PD group were lower than those of the control group.The incidence of olfactory disturbance was 57.6%(38/66)and 25.9%(12/54),respectively.The difference was statistically significant.Significance(P<0.05).The identification test showed that the PD group was significantly worse than the control group(P<0.05)in identifying the six odors of camphor,soap,pepper,peanut butter,chocolate and coffee,and the recognition rate of each olfactor was also lower than that Control group.(2)Analysis of the influencing factors of PD olfactory function,the results showed that the PD group olfactory test scores were not related to the possible influencing factors(sex,depression,age,duration),but related to the severity of the disease.(3)In terms of TCM syndrome differentiation,the blood stasis is the most common,accounting for 37.9%(25/66).The second is for liver and blood deficiency,Fengyang internal movement syndrome,liver and kidney yin deficiency,virtual wind internal movement syndrome,phlegm-heat resistance,and wind-wood internal movement syndrome,but the incidence of olfactory disorder has nothing to do with the distribution of syndrome type(P>0.05).The two groups in the PD group(the olfactory disorder group and the non-olfactory disorder group)were characterized by pathogenic factors(internal heat,blood deficiency,turbidity,yin deficiency)and disease elements(liver,spleen,kidney,lung),and syndromes.The difference in scores was not statistically significant(P>0.05);the scores of the syndromes on the brain of the patients in the two groups were statistically significant(P<0.05);The mean scores of the syndromes were highest in the brain(17.6±2.75)and liver(17.6±2.75).On the etiology and disease factors,the mean scores of the syndromes of blood stasis(17.3±2.42)and yin deficiency(17.6±2.58),respectively.highest.By comparing the frequency distribution,the difference between the two groups of 10 syndromes,the difference in the frequency distribution of the brain and the pathogenic factors in the two groups was statistically significant(P<0.05).On the remaining syndromes,there was no statistical difference between the groups(P>0.05).(4)In the frequency distribution of 10 disease factors and etiological factors,the olfactory disorder group ranked the pathogenic factors: blood deficiency (39.5%),internal heat(42.1%),yin deficiency(50.0%),blood stasis(73.7%),turbidity(76.3%);ranking of disease factors: spleen(36.8%),kidney(50.0%),lung(65.8%),liver(73.7%),brain(84.2%).Non-olfactory disorder group etiology of disease factors: blood stasis(39.3%),internal heat(46.4%),blood deficiency(50.0%),yin deficiency(53.6%),turbidity(78.6%);ranking of disease elements: kidney(46.4%),brain(53.6%),spleen(42.9%),liver(57.1%),lung(64.3%).Conclusions:(1)According to the survey,the incidence of PD dysosmia was higher than that of healthy people,and in the recognition function and olfactory threshold,the PD group decreased compared with the control group;(2)In terms of factors affecting olfactory function,PD olfactory disorder has no correlation with gender,age,depression and course of disease,but it is related to the severity of the disease.The factors affecting the health checkup may be age and depression;(3)There may be no correlation between the distribution of TCM syndrome types and the incidence of olfactory disorders in PD;in terms of syndromes,the most common disease factors in the olfactory disorder group and the non-olfactory disorder group are the brain and liver;the most common The pathogenic factors are blood stasis and yin deficiency.