| Objective:To explore characteristics of Traditional Chinese Medicine (TCM) clinical presentations in the patients of Pakinson’s Disease(PD)with olfactory disorders, and the correlation between TCM syndrome elements and olfactory disorders, which can provide evidence for differentiation of syndromes and treatments in Chinese Medicine.Methods:1 Researchers were trained in the same standard to collect information. Cases of PD were selected from Dongzhimen Hospital and Beijing Hospital between August 2012 and August 2013.101 PD cases were finally included in the study,whose ages vary from 40 to 85,and who is in accordance with Parkinson’s disease diagnostic criteria.In these cases, there are 70 with olfactory disorders,and 31 without olfactory disorders.2 A database was established by EpiData3.1 and statistics were processed by SPSS20.0. All groups were scored referring to the pattern element scale in PD patients (PD-PES-13). Using chi-square test to compare two groups of syndrome elements distribution. And using Spearman correlation analysis to study the correlation between olfactory scores in PD patients associated with olfactory dysfunction and the TCM syndrome elements.Results:1 In the scores of TCM symptoms, scores of elements of encephala reduce are highest in both two groups,then yin deficiency and liver wind.Otherwise, scores of elements of turbid phlegm, blood stasis and qi stagnation are lower.2 The frequnercies of TCM syndrome elements of smell disorders group are as follows: liver wind (85.71%),encephala reduce (85.71%),yin deficiency (80.00%),yang-hyperactivity(70.00%),internal thermal(65.71%),qi deficiency (65.71%),kidney deficiency (65.71%),spleen deficiency (57.14%),blood deficiency (38.57%),yang deficiency (28.57%),turbid phlegm (17.14%),blood stasis (15.71%). Another group:yin deficiency (100.0%),liver wind (90.32%),internal thermal (80.65%),encephala reduce (74.19%), qi deficiency (64.52%),kidney deficiency (61.29%),spleen deficiency (51.61%),yang-hyperactivity(51.61%),blood deficiency(41.94%),yang deficiency(32.26%),turbid phleg-m (19.35%),blood stasis (19.35%)。 The distribution of the syndrome elements between the two groups doesn’t have statistical differences.3 In the PD patients with olfactory disorders, the proportion of female with blood deficiency higher than male. The frequnercies of TCM syndrome elements in all ages have no difference in statistics.4 In the PD patients with olfactory disorders, there is a positive correlation between liver wind and H&Y stage.5 In the PD patients with olfactory disorders, there is a correlation between scores of bilateral smell test and yang-hyperactivity.Conclusion:1 The common TCM syndrome elements of PD patients with olfactory disorders are liver wind,encephala reduce,yin deficiency and yang-hyperactivity. The elements of PD patients without olfactory disorders are yin deficiency,liver wind,internal thermal,encephala reduce.2 olfactory disorders maybe have no influence on the distribution of TCM syndrome elements in PD patients.3 With the development of the disease,the syndrome of liver wind of the PD patients with olfactory disorders also gradually increase4 The syndrome yang-hyperactivity are the risk factor of the bilateral olfactory disorders.
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