Correlative Study On Olfactory Dysfunction Of Patients With Parkinson's Disease

Objective:To study olfactory function in chinese patients with parkinson's disease and to explore the relationship of these changes among its course, its condition, its onset age and the possibility of early diagnosis of Parkinson's disease.Methods:41 cases of diagnosed parkinson's disease were chosed,Among the 41 patients, 23 male and 18 famale.Age range from 44 to 80 years old.Mean age is 61±9.13 years old..Disease course range from 3 months to 13 years.Mean course is 4±2.7 years。all cases were accord with the diagnostic criteria of PD refered to the neurology branch, dyskinesia and parkinson's disease group of Chinese Medical Association(2006).41 cases of healthy families of hospitalised patients and healthy subjects severed as normal controls were chosed,whose age,nationality and gender-matched and cultural degree approximate matching.23 male and 18 female.Age range from 44 to 80 years old.Both groups were the Han nationality.41 PD patients and 41 healthy controls were examined by using MMSE and simple olfactory test. The changes of olfactory function were obtained,the relationship were observed between the changes of olfactory function and the condition,Age or disease course.Results:the incidence of olfactory dysfunction of case group was 82.9%,It's signficantly higher than the healthy controls (26.8%)(P<0.01). The comparison of incidence of olfactory dysfunction and condition show that there were statistical differences between mild PD group and moderate and severe PD group (P<0.05). When we removed the influence of age, there were statistically significant differences between mild PD group and moderate and severe PD group in onset age over the age of 60 group(P<0.05). the incidence of olfactory dysfunction of moderate and severe PD group was higher than mild PD group.No difference was observed between olfacrory function and the age or duration(P>0.05).Conclusion:Olfactory dysfunction may occur to patients with Parkinson's disease and it is unrelated to the age and the course of Parkinson's Disease but is closely related to its condition. Olfactory detection has certain significance in the early diagnosis of Parkinson's disease.