Clinical Study On Treatment Of Wind-heat Type Chronic Spontaneous Urticaria With Jingfang Recipe Combined With Ebastine

1 Research purposes To observe and evaluate the clinical efficacy,safety and recurrence rate of Jingfang Decoction combined with Ebastine Tablets in the treatment of chronic spontaneous urticaria(wind-heat syndrome)and its effects on CRP and IL-17,and to CRP and IL-17 Correlation analysis was performed to evaluate the significance of IL-17 and CRP levels in the severity and prognosis of chronic spontaneous urticaria.2 methods According to the principle of randomized control,84 patients with chronic spontaneous urticaria who met the inclusion criteria were selected in the dermatology clinic of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,and divided into 42 cases in the combination group and the western medicine group.In the health check-up center,40 healthy people whose physical examination indexes were within the normal range were selected as healthy controls.The combination group and the western medicine group were treated with Jingfang prescription plus or without ebastine tablets and Ebastine tablets alone.After 8 weeks of observation,the wheal number score,the pruritus score,the Urticaria activity score(UAS),and the adverse reactions were evaluated in the combined group and the western medicine group before treatment,4 weeks of treatment,and 8 weeks of treatment.The Dermatology life quality index(DLQI)of the combined group and western medicine group was evaluated before treatment and after 8 weeks of treatment.The venous blood of the combined group,the western medicine group and the healthy control group was extracted 5 ml,and the two indexes of CRP and IL-17 were detected.The differences of serum indexes before treatment between the combined group,western medicine group and healthy control group were compared and observed before treatment in the combined group and western medicine group.Changes in serological indicators with treatment for 8 weeks.The patients in the combined group and the western medicine group were followed up for 12 weeks after the end of 8 weeks of treatment to evaluate the recurrence rate.The data obtained were analyzed using SPSS 23.0 software.3 results(1)Analysis of curative effect: 1 combined group treatment cured 9 people at 4 weeks,20 effective,10 effective,1 invalid,the total effective rate was 72.5%;Western medicine group cured 7 people at 4 weekends,markedly effective 16 people,effective11 people Invalid 8 people,the total effective rate was 54.76%.The difference between the combined group and the western medicine group was statistically significant(P<0.05).The 2 combined group cured 21 people at the end of the 8th week,14 effective,8 effective,6 invalid.The total effective rate was 87.5%;the western medicine group cured 11 people at the end of 8 weeks,17 were effective,8 were effective,6 were ineffective,and the total effective rate was 66.67%.There was significant difference between the combined group and the western medicine group(P<0.01).(2)Analysis of curative effect indicators: comparison within 1 group: the scores of wheal group,pruritus symptom score,UAS,etc.decreased in the combined group and western medicine group,and there was no statistical difference in the group(P<0.05);There was no statistical difference(P>0.05)at 4 weeks of treatment,and the combination group was superior to the western medicine group at 8 weeks of treatment(P<0.05).DLQI decreased after treatment in both groups,and the DLQI index of the combined group was significantly better than that of the western medicine group(P<0.01).(3)Safety analysis: There were no serious adverse reactions in the combined group and western medicine group.The incidence of adverse reactions were 2.5% and 4.76%,respectively.There was no significant difference between the two groups(P>0.05).(4)Recurrence rate analysis: The recurrence rate of the combined group and the western medicine group was 9.52% and 45.45% at 12 weeks after the end of 8 weeks,and the difference was statistically significant(P<0.05).(5)Changes of serum CRP and IL-17 in the three groups: 1 There was no significant difference between the two groups before treatment(P>0.05),and there were significant differences between the two groups(P>0.05).<0.05)2 There was significant difference in IL-17 levels between the combination group and the western medicine group before treatment and after 8 weeks of treatment(P<0.01),and the CRP levels were significantly different(P<0.01).(6)Serum IL-17 levels in patients with severe CSU were significantly higher than those in patients with mild CSU(P<0.01).There were statistics on serum IL-17 levels in patients with moderate CSU and mild CSU.Academic significance(P<0.05),serum IL-17 levels in patients with moderate CSU and severe CSU were statistically significant(P<0.05);CRP levels in patients with severe CSU were higher than those in patients with mild CSU,and there were significant differences(P<0.05).P<0.01),serum CRP levels in patients with severe CSU and mild CSU were statistically significant(P<0.01).There was no significant difference in serum CRP levels between patients with mild CSU and those with moderate CSU(P>0.05).).(7)There was no correlation between serum IL-17 and CRP levels in the combination group,western medicine group and healthy control group(p<0.05).4 Conclusion(1)Jingfang combined with ebastine tablets in the treatment of chronic spontaneous urticaria(wind-heat type)has no obvious adverse reactions,the curative effect is exact,and it is better than the simple ebastine tablets in improving the cure rate and reducing the recurrence rate.(2)IL-17 levels in patients with chronic spontaneous urticaria are closely related to the severity of the disease,and CRP levels may be To determine the severity of chronic spontaneous urticaria.(3)The increase of serum IL-17 concentration in patients with chronic spontaneous urticaria may be an independent indicator of systemic inflammatory response in CU,and has nothing to do with elevated CRP levels.