Clinical Significance And Correlation Analysis Of D-dimer And C-reactive Protein In Children With Mycoplasma Pneumoniae Pneumonia

Objective:To explore the significance and correlation of coagulation parameters(D-dimer)and inflammation index(C-reactive protein)in children with Mycoplasma pneumoniae pneumonia.Methods:From January 2017 to December 2018,863 children with Myeoplasma Pneumoniae Pneumonia who were hospitalized in the Department of Pediatrics Medicine,first Hospital of Jilin University were divided into simple MPP group(240 cases of MP group),MPP group with bacterial infection(188 cases of MP&bacterial group)and MPP group with CP infection(312 cases of MP&CP group)according to the pathogens infected,3 groups in total,36 patients were extracted from each group by simple random sampling method,and a total of 108 patients were selected as subjects.Compared the changes of the clinical data(fever time,heat peak,irritating severe cough time and hospitalization time),coagulation parameters(PT,APTT,FIB,PLT and D-D),inflammatory markers(WBC counts,NE% and CRP)of each group,counted the incidence of severe pneumonia and related complications in each group,analyzed the correlation between D-D and CRP in each group and explored its clinical significance.The data were analyzed by SPSS 19.0 software.The normal distribution of the measurement data was measured by the mean± standard deviation(x ±s),and the non-normal distribution of the measurement data using the median,quartile [M(Q1,Q3)].The count data was described by the composition ratio(%).Multiple sets of measurement data were performed using(Kruskal-Wallis)multiple independent sample rank sum test.If it is difference,Bonferroni method is used for comparison.Qualitative data comparison was performed by χ2 test.Correlation analysis was performed by Spearman rank correlation analysis.Results:There were statistically significant(P<0.05)differences of the three groups in fever time,severe cough time,hospitalization time,plasma levels of FIB,D-D,CRP,WBC counts,NE%,the incidence of severe pneumonia and related complications.There were no significant differences in the comparison of heat peak,plasma levels of PT,APTT and PLT counts(P>0.05).Among them:1.Compared with the MP group,plasma levels and the incidence of severe pneumonia and related complications of D-D,CRP and NE% in the MP & bacterial group were all significantly increased,and hospitalization time was significantly prolonged.The difference was statistically significant(P <0.05);There was no significant difference in the duration of fever and irritation of severe cough,FIB levels and WBC counts between the two groups(P>0.05).Compared with the MP group,the fever time of the MP&CP group was prolonged,and plasma levels of FIB,D-D and CRP,WBC counts and NE% were significantly increased(P<0.05).There was no significant difference in the severe cough time,length of hospital stay,the incidence of severe pneumonia and complications of the two groups(P>0.05).Compared with the MP&CP group,the severe cough time and hospitalization time were significantly prolonged in the MP & bacterial group,and the incidence of complications was significantly increased.The difference was statistically significant(P<0.05).There was no significant difference in the two groups in fever time,plasma levels of FIB,D-D,CRP,WBC counts,NE% and the incidence of severe pneumonia(P>0.05).Correlation analysis between D-D and CRP levels in each group: There was no correlation between D-D and CRP in MP group,D-D and CRP were positively correlated in the MP&bacterial and MP&CP groups.Conclusion:1.Children with MPP with bacterial or CP infection were more prone to hypercoagulablity than those with simple MPP.2.Children with MPP with significantly elevated CRP should be tested for D-D as soon as possible to alert for abnormal coagulation.3.Children with MPP with simultaneously increased D-D and CRP should be alert to mixed infections.Children with MPP with bacterial infection are more likely to develop severe pneumonia and related complications.