| Objective:The Patients with insomnia of deficiency of heart and spleen and stagnation of liver were treated by shugan jianpi anshen acupuncture,To observe the effect of shugan jianpi anshen acupuncture on monoamine neurotransmitter 5-hydroxytryPtamine(5-ht)secreted by HPA axis Pathway and sleep quality in insomnia Patients,To expound the mechanism of shugan jianpi anshen acupuncture in treating insomnia of deficiency of heart and spleen with liver depression.Methods:Ninety cases of insomnia Patients with the syndrome of deficiency of heart and spleen combined with liver depression that met the diagnostic and inclusion criteria were included,Using a random number table,the patients were randomly divided into acupuncture group,comprehensive group,and drug group,with 30 cases in each group.The acupuncture group was treated with Shugan Jianpi Anshen Acupuncture,and the comprehensive group was given Shugan Jianpi Anshen Acupuncture and aprazolam tablets,Acupuncture group,comprehensive group 5 times a week,Saturday,Sunday rest,consecutive 2 weeks.The drug group was treated with alprazolam tablets,2 tablets per day for 12 consecutive days,The curative effect was observed in all three groups after 12 days,followed by one month.After the end of treatment,the three groups of patients were judged by nimodipine method,Determination of serum serotonin levels before and after treatment by high performance liquid chromatography,Patients in the three groups were graded by Pittsburgh sleep quality index(PSQI)and TCM syndrome score scale before and after treatment and after follow-up,The data were statistically processed to evaluate the short-term and long-term clinical efficacy.Results:1.After treatment,the total effective rate of acupuncture,comprehensive and drug groups was 90.0%,93.3%,70%,respectively,The total effective rate of the three groups was different(P<0.05),There was no difference in the total effective rate between the acupuncture group and the comprehensive group(P>0.05),The total effective rate of acupuncture group and comprehensive group was better than that of drug group(P < 0.05).2.After treatment,the TCM symptom scores of the three groups were lower than those before treatment(P<0.05),There was no difference in the scores between the acupuncture group and the comprehensive group after treatment(P>0.05),The scores of the acupuncture group and the comprehensive group were significantly lower than those of the drug group(P<0.01),It showed that the acupuncture group and the comprehensive group improved the symptoms of insomnia better than the drug group.After follow-up,the TCM symptom scores of the acupuncture group and the comprehensive group were lower than those before treatment(P<0.05),The follow-up score of drug group was higher than those after treatment(P < 0.01),After follow-up,the scores of acupuncture group and comprehensive group were significantly lower than those of drug group(P < 0.01),It indicates that the long-term effect of acupuncture group and comprehensive group on insomnia symptoms is better than that of drug group.3.After treatment,the Pittsburgh Sleep Quality Index(PSQI)scores of the three groups were lower than those before treatment(P<0.05),The total score of PSQI and the scores of each item in the acupuncture group and the comprehensive group were significantly lower than those in the drug group(P<0.01),There was no difference in the scores of PSQI scores and PSQI scores between the acupuncture group and the comprehensive group after treatment(P>0.05),It indicated that the acupuncture group and the comprehensive group improved the sleep quality better than the drug group;After the follow-up,the total scores of PSQI and the scores of each item in the acupuncture group and the comprehensive group were lower than those before treatment(P<0.05),The total PSQI score and the scores of each item in the drug group after follow-up were higher than that after treatment(P < 0.01),After the follow-up,the total score of PSQI and the scores of each item in the acupuncture group and the comprehensive group were significantly lower than those in the drug group(P<0.01),It indicates that the long-term effect of acupuncture and moxibustion group and comprehensive group on improving sleep quality is better than that of drug group.4.After treatment,the levels of serotonin(5-HT)in the acupuncture group and the comprehensive group were significantly different from those before treatment(P<0.01),After treatment,the 5-HT content of the drug group was no different from that before treatment(P>0.05),The 5-ht content of the three groups after treatment was significantly different(P < 0.01),There was no difference in the 5-HT content between the acupuncture group and the comprehensive group(P>0.05),The 5-HT levels in the acupuncture group and the comprehensive group were significantly higher than those in the drug group(P<0.01).Conclusion:1.The short-term and long-term clinical effects of shugan jianpi anshen acupuncture on improving sleep quality of insomnia patients with deficiency of heart and spleen combined with liver depression are better than conventional drug therapy,It can improve the symptoms of insomnia,improve the quality of sleep,and is safe and simple without adverse reactions.2.Shugan jianpi anshen acupuncture on insomnia patients with HPA axis neurotransmitter 5-hydroxytryptamine content increased,Elevated serotonin levels are associated with improved sleep quality,The effect of this acupuncture on improving the level of serotonin is the mechanism of improving sleep quality. |
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