| Objective: The clinical observation was conducted on insomnia patients with deficiency of heart and spleen combined with liver depression by using the shugan jianpi anshen acupuncture.Serum dopamine level,Pittsburgh sleep quality index(PSQI)and TCM syndrome score were used as evaluation indexes.To explore its effect on serum dopamine levels and sleep quality in patients with insomnia,confirm the mechanism and efficacy of shugan jianpi anzhen acupuncture on insomnia and use it to guide clinical application.Method:90 insomnia patients with deficiency of heart and spleen combined with liver depression who met the inclusion criteria were divided into acupuncture group,drug group and comprehensive group with 30 cases in each group by random number method.The acupuncture group was treated with Shugan Jianpi Anzhen Acupuncture Method(mainly Shugan Jianpi Acupoint),the drug group was treated with oral alprazolam,the comprehensive group was treated with Shugan Jianpi Anzhen Acupuncture Method combined with oral administration of alprazolam.Acupuncture treatment was performed5 times a week for 2 weeks with rest on Saturdays and Sundays,drug treatment once a day for 12 consecutive days,all three groups were observed after 12 days and followed up after 1 month.The efficacy of pre-treatment,post-treatment and follow-up was evaluated in three groups of patients using PSQI and TCM syndrome scores,simultaneous detection of serum dopamine levels before and after treatment in three groups of patients,Analysis of the difference in efficacy between the three groups by SPSS21.0 statisticalsoftware analysis.Results:1?After treatment,the levels of serum dopamine in the acupuncture group and the comprehensive group were significantly lower than those in the drug group(P<0.01),but there was no statistically significant difference between the two groups(P>0.05).The results showed that the acupuncture group and the comprehensive group were significantly better than the drug group in reducing the serum dopamine level,but there was no difference between the two groups.2?After treatment,PSQI scores of the acupuncture group and the comprehensive group were significantly lower than those of the drug group(P<0.01),but there was no statistically significant difference between the two groups(P>0.05).The results showed that the acupuncture group and the comprehensive group were better than the drug group in improving sleep quality,but there was no difference in the efficacy between the two groups.After the follow-up,the PSQI scores of the acupuncture group and the comprehensive group were significantly lower than those before the treatment(P<0.01).There was no significant difference in the PSQI score between the drug group and the pre-treatment(P>0.05).After the follow-up,the PSQI scores of the acupuncture group and the comprehensive group were significantly lower than those before the treatment(P<0.01),but there was no significant difference in the PSQI score between the drug group and the pre-treatment(P>0.05).After follow-up,the differences between the acupuncture group and the comprehensive group and the drug group were statistically significant(P<0.05),but the differences between tthe acupuncture group and the comprehensive group were not statistically significant(P>0.05).It indicates that the acupuncture group and the comprehensive group have better long-term efficacy in improving the PSQI score of patients,and both of them are better than the drug group,but there is no difference between the two groups.3?After treatment,TCM syndrome scores in the acupunctureand moxibustion group and the comprehensive group were significantly lower than those in the drug group(P<0.01),but there was no statistical difference between the two groups(P>0.05).The results showed that the acupuncture group and the comprehensive group were better than the drug group in improving the efficacy of TCM syndromes,but there was no difference in the efficacy between the two groups.After follow-up,the scores of TCM syndromes in the acupuncture group and the comprehensive group were significantly lower than those before treatment(P<0.01),while the differences between the drug group and before treatment were not statistically significant(P>0.05).The acupuncture group and the comprehensive group were compared with the drug group respectively,the scores of TCM syndromes were all lower than those of the drug group(P<0.05),but there was no significant difference between the two groups(P>0.05).It shows that the acupuncture group and the comprehensive group have better long-term effects in improving TCM syndromes,and both are superior to the drug group,but there is no difference between the two groups.4?The total effective rates of the acupuncture group,the drug group and the comprehensive group were90.0%,70% and 93.3%,respectively.The total effective rates of the acupuncture group and the comprehensive group were both higher than the drug group(P<0.05),and the difference between the acupuncture group and the comprehensive group was not statistically significant(P>0.05).Conclusions: 1?The shugan jianpi anshen acupuncture to reduce the serum dopamine level was significantly better than the drug group,and there was no difference in the efficacy compared with the comprehensive group.2? The shugan jianpi anshen acupuncture to reduced the PSQI score,improved the quality of sleep and the TCM syndrome score was significantly better than the drug group.There was no difference in efficacy compared with the comprehensive group.3 ? The Shugan jianpi anshen acupuncture caneffectively improve the sleep quality,clinical symptoms and adverse emotions of patients with insomnia,and its mechanism of action is related to the reduction of dopamine levels.3?As a single treatment method,shugan jianpi anshen acupuncture has incomparable advantages,such as simple operation,no dependence and addictionhigh,safety and cure rate.It could also reduce the cost of treatment for patients,obvious long-term curative effect and other advantages to provide a new treatment method for the treatment of insomnia patients with deficiency of heart and spleen combined with liver depression. |
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