The Distribution Of Anterior Chamber Depth And Lens Thickness Of 1541 Preschool Children Aged 48 To 60 Months

Objective:To study the distribution of anterior chamber depth and lens thickness of 1541 preschool children aged 48 to 60 months and to explore the relationship with the anthropometric parameters.Methods:Nanjing Eye Study(NES)is a cohort Study based on population,with the aim of observing the development of children with eye diseases in Nanjing,China.This study is part of Nanjing Eye Study.In 2016,the team was recruited 2,300 children aged 48 to 60 months in Yuhuatai district,Nanjing,to measure and record height and weight,and calculate the body mass index(BMI).Using Lenstar LS 900(Haag-Streit Koeniz,Switzerland)to measure the anterior chamber depth(ACD)and lens thickness(LT)of these children.There were 1,541 kindergarten students,829 boys and 712 girls,with an average age of 54.92±3.51 months,The differences of ACD and LT in different month age groups were analyzed using one-way anova,and the correlation was used by bivariate correlation and partial correlation for statistical analysis.Results:A total of 1986 children agreed to receive an ophthalmological examination,with a responsive rate of 86.35%.Of these,1,541 children had complete ACD and LT results.The mean average of the ACD and LT of 1541 children aged 48 to 60 were 2.71±0.25mm and 3.81±0.23mm,respectively,both of them were non-normal distributions.In the monthly age group,the ACD in 2 groups,3 groups,and 4 groups were normal distribution(P=0.2<0.05),and in 1 group of non-normal distribution(P<0.01),the LT was also non-normal distribution in each group(P<0.01).With the increase of the monthly age,the depth of the anterior chamber was deeper and the lens thickness was thinner(P<0.01).The mean average of boys of ACD and LT were 2.77±0.24mm and 3.81±0.23mm respectively.The mean average of girls of ACD and LT were 2.64±0.25mm and 3.84±0.24mm respectively.The gender difference between ACD and LT values was statistically significantly relative(P<0.01).Spearman analysis was used in the correlation of ocular and anthropometric parameters.The ACD was significantly positively correlated with height,weight and BMI(rs=0.176,rs=0.156,rs=0.070,all P<0.01).The LT was significantly negatively correlated with height(r=-0.123,P<0.01),which was not correlated with body weight and BMI(rs=-0.050,P=0.077>0.05;Rs=0.042,P=0.137>0.05).In the multivariate linear regression analysis model,When the risk factors were not corrected,the height was increased by 1cm,the ACD increased by 0.01mm and LT was 0.006mm(both P<0.001).The weight was increased by 1Kg,the ACD increased by 0.015mm and LT decreased 0.006mm(P<0.05).The ACD was increased by 0.006mm(P<0.001)per unit of BMI,which was not associated with the LT.After adjusting the monthly age and gender,the multivariate linear regression analysis model showed that the height was increased by 1cm,the ACD increased by 0.008mm and the LT thinner 0.004mm(both P<0.01).For every 1Kg increased in weight,the ACD was deepened 0.012mm(P<0.001).The weight was not associated with the LT,and BMI was not associated with the ACD and LT(all P>0.05).Conclusion:In preschool children aged from 48 to 60 months,the distribution of anterior chamber depth and lens thickness was negative skewness.The anterior chamber depth of the boy was longer than the girl,however the lens thickness was shorter than the girl.The higher the height,the longer the anterior chamber depth and the shorter the lens thickness.The more the weight,the longer the anterior chamber depth.