| PurposeTo evaluate ocular biometric parameters in school-aged children. To investigate the association between ocular biometrics with different refractive errors and evaluate the contribution by the ocular components to the emmetropization of spherical equivalent refractive error, which may provide a route to the prevention and control of myopia.Materials and MethodsThis study is a retrospective cohort study. All children underwent complete ophthalmologic examination, with three years of continuous measurement on spherical equivalent refraction and ocular biometric parameters.First grade school students were chosen in Beijing including Dongcheng and Huairou. Vision screening questionnaire included, but not limited to, sex, DOB, personal or parental history of eye disease, past medical records on comprehensive eye and vision examination.Ophthalmologic examination includes uncorrected visual acuity(UCVA)and best corrected visual acuity, near visual acuity, slit lamp for anterior segment,fundus photography, auto-refraction, subjective refraction eye movement examination. Ocular biometry parameters includes ocular axial length(AL), central corneal thickness(CCT), corneal radius(CR), anterior chamber depth(ACD),lens thickness(LT). According to the refraction, the participants were divided into three groups, non-myopia group(both 2011 and 2014 check did not show myopia),new myopia group(myopia in 2014 but no myopia in 2011) and myopia group(myopia was noted in 2011 and 2014). Progression of myopia and change of parameters were compared between groups.ResultsA total of 167 school-age children were in accordance with the inclusion criteria.The mean age was 6.3±0.4 years at baseline 43.1% were girls. Non-myopia group was 105 cases. New myopia group included 45 students. Myopia group included 17 cases.UCVA, SE, AL, CR were significantly different between 2011 and 2014(Z =-7.191,-6.583,-10.814, P = 0.000); AL, CCT, ACD, LT difference was statistically significant(t =-23.134,-3.496,-18.488, 16.058, P = 0.000, 0.001, 0.000, 0.000).LT difference was statistically significant in 2011 between non-myopia group and new myopia group(P = 0.004); UCVA, SE, AL, ACD, AL/CR difference were statistically significant between non-myopia group and myopia group(P =0.000),between new myopia group and myopia group(P = 0.000, 0.000, 0.029, 0.000,0.029). In 2014, UCVA, SE, AL, ACD, LT, AL/CR difference were statistically significant between new myopia group and non-myopia group(P = 0.000, 0.000,0.000, 0.016, 0.004, 0.000); between nonmyopia group and myopia group(P = 0.000);UCVAt, SE difference were statistically significant between new myopia group and myopia group(P = 0.000, 0.001).AL was associated with CR(r = 0.785, 0.399, 0.689, P = 0.000, 0.000, 0.002)(r= 0.747, 0.671, 0.665, P = 0.000, 0.007, 0.004) among the three groups in 2011 and2014; AL and SE were obviously correlated(r =-0.834, P = 0.000) in myopia group in 2014. ACD was associated with LT(r =-0.505,-0.561,-0.481, P = 0.000, 0.000,0.051)(r =-0.337,-0.620,-0.685, P = 0.000, 0.000, 0.004) in 2011 and 2014 among the three groups. AL/CR was related with SE(r =-0.698,- 0.707, P = 0.000, 0.001) in2014 among new myopia group and myopia group. ACD/LT was associated with AL(r = 0.599, 0.602, P = 0.000, 0.011) in 2014 among new myopia group and myopia group. AL/LT was associated with SE(r =-0.545,-0.787, P = 0.000) in 2014 among new myopia group and myopia group.ConclusionsThree years follow up observations indicated that the eyes showed significant SE decrease, AL increase, CCT thickening, ACD deepen, LT thinning, AL/CR increase.LT may be an early warning signal of myopia development.AL/LT significantly correlated with SE and the increasing of myopia, AL/CR and SE may predicted the incident of myopia. |
PDF Full Text Request