Potential Risk Factors Of Osteoporosis Among Middle-aged And Elderly Population In China:Based On Dongfeng-tongji Cohort

Objective: To investigate the prevalence and potential risk factors of osteoporosis(OP)in the middle-aged and elderly population in China.Methods: We conducted a cross-sectional study based on Dongfeng-Tongji cohort,which included 30916 individuals in the first follow-up from April to October in 2013.Quantitative ultrasound system was used to measure bone mineral density(BMD)of the anklebone.Semi-structured questionnaires,physical and biochemical examinations were completed at the same time.Logistic regression analysis was used to explore the potential risk factors for osteoporosis.Results: Prevalence of osteoporosis in all participants,male and female subgroup was 42.3%,35.0% and 48.3%,respectively.In <65,65-70,70-75,75-80 and ? 80 years old subgroup,prevalence of osteoporosis was 37.7%,41.7%,51.4%,52.4% and 54.6%,respectively.Older age,lower BMI,lack of exercise,abnormal elevated serum ALP,abnormal elevated serum ?-GT and abnormal elevated serum AST/ALT were risk factors for osteoporosis either in male or female group.In males,we also found significant associations of smoking and drinking with increased risk of osteoporosis.In females,we also found a significant association of menopause with increased risk of osteoporosis.Participants with the highest quartile of ALP,?-GT and AST/ALT had highest risks for osteoporosis [OR=1.687(95% CI: 1.538-1.851),OR=1.136(95% CI: 1.037-1.245),OR=1.347(95% CI: 1.223-1.482),respectively].Furthermore,the risk of osteoporosis was significantly associated with abnormal elevated serum levels of ALP,?-GT and AST/ALT in dose-response relationships,both in male and female group(all P for trend < 0.05).Conclusions: The prevalence of osteoporosis increased with age in the middle-aged and elderly population.The occurrence of osteoporosis was related with many factors.In addition to the traditional risk factors(such as age,gender and smoking),abnormal elevated serum ALP,?-GT and AST/ALT were also the risk factors for osteoporosis.Considering these risk factors,taking appropriate measures would contribute to prevent the occurrence of osteoporosis.