Clinical Study Of Runfei Xiaozheng Decoction Combined With Chemotherapy In Treating Advanced Non-small Cell Lung Cancer(Qi-yin Deficiency Type)

Objective:To observe Solid tumor target lesions,TCM symptoms,KPS score,body weight,and toxicity of Runfei Xiaozheng Fang combined with chemotherapy(treatment group)and chemotherapy alone(control group)in patients with advanced non-small cell lung cancer(qi-yin deficiency syndrome).The impact of the reaction was evaluated on the clinical value of Chinese medicine combined with chemotherapy in the treatment of non-small cell lung cancer(NSCLC),providing certain clinical data for the establishment of a comprehensive treatment model for lung cancer.Methods:In this study,a prospective,randomized,controlled study method was used to collect 71 NSCLC patients who met the inclusion criteria in the Inpatient Department of Sichuan Provincial Hospital from February 4,2016 to October 18,2017.According to the random number table,they were randomly divided into trial group(36 cases)and control group(35 cases).Both the experimental group and the control group were treated with GP regimen chemotherapy.The experimental group was combined with Runfei Xiaozheng Fang on the basis of chemotherapy alone.It was followed for 2 cycles(21 days for one cycle).The Solid tumor target lesions,TCM symptom score and KPS score were recorded.,body weight,chemotherapy toxicity,and assess drug safety,in order to evaluate the role of Runfeixiaozheng Fang.SPSS18.0 software was used for statistical analysis.Results:Comparing the data before treatment(P>0.05)between the experimental group and the control group,the differences were not statistically significant and comparable.After treatment,the efficacy of target lesions of solid tumors in both groups was tested by Mann-Whitney test,P>0.05,and no statistical significance was found;The KPS scores of the two groups were examined by Mann-Whitney test,showing statistical significance(P<0.05);The efficacy scores of TCM and scores of TCM symptoms between the two groups were statistically significant by Mann-Whitney test(P<0.05);There was no statistical significance between the weights of the two groups by two independent samples t-test(P>0.05),but the weight in the group was statistically significant by two-pair t-test(P<0.05);The comparison of electrocardiogram,hemogram,liver and kidney function,and malignant vomiting between the two groups was not statistically significant by the Mann-Whitney test(P>0.05).Changes in diarrhea between the two groups were statistically significant by the Mann-Whitney test(P<0.05).Conclusion: 1.In the efficacy of solid tumor target lesions,Runfei Xiaozheng Fang combinedwith chemotherapy for treatment of advanced qi and yin deficiency NSCLC wasnot significantly different than chemotherapy alone.2.In terms of KPS scores and TCM symptoms,Runfeixiaozheng Fang combinedwith chemotherapy can improve KPS scores,relieve symptoms and improve thequality of life of patients compared with chemotherapy alone.3.In terms of body weight,Runfeixiaozheng Fang combined with chemotherapy hasa tendency to increase the weight of patients,but compared with chemotherapyalone,there is no significant difference.4.In terms of toxicities and side effects,Runfeixiaozheng Fang combined withchemotherapy than chemotherapy alone can reduce the diarrhea response causedby chemotherapy,improve patient tolerance to chemotherapy.