Ganzhikang Decoction In The Treatment Of Nonalcoholic Steatohepatitis(damp Heat Retention Syndrome)Clinical Research

Objective:The purpose of this study is to explore the clinical effect of Gan Zhi Kang Fang on non-alcoholic steatohepatitis(damp heat syndrome),and to evaluate the treatment of this disease from the comprehensive effect of the disease,the syndrome effect,the integral of the total symptoms of TCM,the observation index,the safety index and so on.The aim is to provide more choices and better results for the treatment of this disease.Method: In Henan Traditional Chinese Medicine Hospital(the Second Affiliated Hospital of Henan University of traditional Chinese Medicine),the subjects of non alcoholic steatohepatitis(NASH)in the liver,gallbladder,spleen and stomach department,two district,three District outpatient and inpatient department,estimated the sample size according to the efficiency of two kinds of pre drug test.According to 10% cases,82 patients were proposed to be included in study.the principle of 1: 1distribution was divided into two groups: the treatment group and the control group,with 41 cases in each group.The treatment group was given the decoction of Gan Zhi Kang,the control group was given the Chinese patent medicine when the capsule was treated with Dang Fei Li Gan Ning capsule.The two groups were all 12 weeks(a total of 1 courses).The data and indexes were collected before and 12 weeks respectively.After 8 weeks of treatment,two groups of patients were followed up to observe long-term effects and adverse reactions.Results:(1)Comprehensive curative effect: after 12 weeks of treatment,the comprehensive curative effect of the two groups was improved,and the treatment group(95.12%)had an advantage over the control group(78.05%)in the comprehensive effect,and the difference was statistically significant(P < 0.05).(2)after the treatment,the curative effect of the two groups of drugs was compared.The treatment group(97.56%)was obviously superior to the control group(85.37%),and the two groups were statistically significant(P < 0.05).(3)observation index: after 12 weeks(a total of 1 courses of treatment),the two groups improved the liver function index(ALT,AST,GGT),blood lipid index(TG,CHOL,HDL,LDL),Fibro Scan(CAP,E),body mass index(BMI)and liver color doppler,and the treatment group was obviously superior to the control group(P < 0.05).(4)symptom integral: the two groups can reduce the score of total symptom score,and the treatment group is better than the control group.There is a difference between the two groups(P < 0.05).(5)the long-term effect: In the treatment group,36 cases were followed up continuously,the continuous effective rate was 87.80%,the control group was 22 cases continuous,and the continuous effective rate was 53.66%.the treatment group was superior to the control group(P < 0.05).(6)Safety: there was no adverse reaction during treatment between the treatment group and the control group.Conclusion:(1)the treatment of nonalcoholic steatohepatitis(damp heat syndrome)has a definite effect,which can obviously reduce the symptoms and signs of the patients and improve the quality of life of the patients.(2)significantly improve the liver function of patients,reduce blood lipids and body mass index.(3)reduce the degree of hepatic steatosis and have a certain effect on liver fibrosis.(4)the curative effect is safe and reliable,and the recurrence rate of treated patients is low.It is an effective prescription for treating non-alcoholic steatohepatitis.