Clinical Study Of Ruyi Jiangmeifang In The Treatment Of Hepatobiliary Damp-heat Non-alcoholic Steatohepatitis

Objective:To observe the clinical efficacy of ruyi jiangmeifang in treating hepatobiliary damp-heat NASH,and to explore the basis of treating non-alcoholic steatohepatitis from damp-heat.Methods:patients with nonalcoholic steatohepatitis were randomly divided into treatment group and control group.There were 30 patients in both groups.The treatment group was treated with ruyi jiangmeifang combined with polyenephosphatidylcholine,and the control group was treated with polyenephosphatidylcholine.The treatment course was 6 weeks,recorded every 3 weeksResults:(1)Comparison of TCM syndromes:after 3 weeks of treatment,the symptoms and signs of the two groups were compared,with flank swelling pain,conscious fatigue and tiredness,dry and sticky mouth,fat body,yellow urine,uncomfortable stool,red tongue or thin yellow or greasy tongue.There were statistically significant differences(P<0.05);after 6 weeks of treatment,the symptoms and signs of the two groups were compared,with flank swelling pain,conscious fatigue and tiredness,dry and sticky mouth,fat body,yellow urine,uncomfortable stool,red tongue or thin yellow or greasy tongue.There were statistically significant differences(P<0.05).The total scores of syndromes in the two groups were compared,There were statistically significant differences(P<0.05).(2)Comparison of liver function and comparison of blood fat:after 3 weeks of treatment,liver function improved.ALT,AST,GGT,ALP,TBIL,DBIL,TG,TC in the two groups were compared with those before treatment,P<0.05,and the difference was statistically significant.ALT,GGT,ALP,TBIL,DBIL,TG,TC were statistically significant between the two groups(P<0.05).After 3 months of treatment,liver function improved.ALT,AST,GGT,ALP,TBIL,DBIL,TG,TC in the two groups were compared with those before treatment,P<0.05,and the difference was statistically significant.GGT,TBIL and DBIL between the two groups were statistically significant(P<0.05).This indicates that the treatment group is superior to the control group in improving GGT,TBIL and DBIL.(3)Comparison of abdominal b-ultrasonography degree:there was no significant difference between the treatment group and the control group in the improvement of abdominal b-ultrasonography degree.Conclusion:for non-alcoholic steatohepatitis patients with hepatobiliary dampness-heat,attention should be paid to clearing away heat and promoting dampness.Ruyi jiangzefang is an effective preparation for the treatment of hepatobiliary damp-heat non-alcoholic steatohepatitis,It can improve the symptoms and signs of patients such as flank pain,conscious fatigue and tiredness,dry and sticky mouth,fat body,yellow urine,uncomfortable stool,red tongue or thin yellow or greasy tongue,etc.It can reduce the liver transaminase and blood fat,and did not see clear adverse reactions,It is worth further promotion and research.