Effect Of Electroacupuncture On The Expression Of Serum Anti-inflammatory Cytokines In Patients With Acute Cerebral Infarction

ObjectiveTo observe the effect of electroacupuncture on serum anti-inflammatory factors SOCS-3,IL-10 and IL-37 in patients with acute cerebral infarction and to evaluate the clinical effect of electroacupuncture on acute cerebral infarction.Methods(1)Select 70 patients who were admitted to the Department of Neurology of Foshan City Hospital from July 2017 to February 2018 and were diagnosed as ACI and were within 1 week of onset.Randomly divided into two groups,including electroacupuncture group(basal treatment + electricity)Acupuncture included 35 cases(4 cases of posterior shedding)and 35 cases(basal treatment)of the control group(6 cases of posterior shedding).Another 30 cases of healthy subjects who matched the age of the same period were selected for reference only;(2)Reference to National Health Research Hospital Stroke Scale(NIHSS),which assessed the clinical efficacy of the two groups of patients after treatment for 14 days;(3)detected serum anti-inflammatory cytokines(SOCS-3)on the 7th day after treatment and before treatment by enzyme-linked immunosorbent assay(ELISA).,IL-10,IL-37)levels;(4)according to the imaging Adama classification statistical analysis of all patients with cerebral infarction area,and analysis of the relationship between pre-treatment blood anti-inflammatory cytokine levels and cerebral infarction area.(5)Results Statistical analysis of data using SPSS 22.0.Results(1)The mean NIHSS scores of the electroacupuncture group were lower than those of the control group;the levels of serum IL-10 and SOCS-3 in the(2)ACI patients were higher than those in the normal healthy population,with significant difference P<0.05(3)Pretreatment serum in the electroacupuncture group and control group There was no significant difference in IL-10 level(P>0.05).On the 7th day after treatment,the expression of IL-10 in the treatment group was higher than that in the control group(P<0.05).Electroacupuncture group and control group There was no significant difference in serum IL-37 levels before treatment(P>0.05).On the 7th day after treatment,the expression of IL-37 in the control group was lower than that in the electroacupuncture group,with significant difference(P<0.05);electroacupuncture There was no significant difference in serum scos-3 level between the two groups before and after treatment(P>0.05).On the 7th day after treatment,the expression of IL-37 in the control group was lower than that in the electroacupuncture group,with significant difference(P<0.05).(4)There was no significant correlation between the change of NIHSS score and the levels of serum anti-inflammatory cytokines IL-10,IL-37 and SOCS-3.Conclusions(1)Electroacupuncture is an effective method to improve neurological deficits after cerebral infarction.Electroacupuncture can improve the neurological score after cerebral infarction;(2)Inflammatory factors participate in the inflammatory response to cerebral ischemia in ACI,serum IL-10 after ACI,scos-3The level of blood serum is higher than that of healthy people.Serum levels of anti-inflammatory cytokines IL-10 and scos-3 may be helpful for prompting early infarction.(3)Electroacupuncture may regulate the expression of anti-inflammatory cytokines in patients with ACI,and may up-regulate anti-inflammatory factors.IL-10 inhibited the down-regulation of IL-37 and socs-3 in vivo,which may be the mechanism of neuroprotection of electroacupuncture;(4)The changes of anti-inflammatory cytokines IL-10,IL-37,SOCS-3 and NISHH Relevance may be related to shorter observation time.