Study On Distribution Characteristics And Associated Factors Of TCM Syndromes In Advanced Colon Cancer In Sichuan

Objectives:(1)To analyze the distribution of clinical symptoms of advanced colon cancer in Sichuan area,and to summarize the TCM syndrome types by the cluster analysis of the four TCM information of patients,and then by more than two TCM and Chinese and Western medicine experts combined with professional knowledge.To summarize the distribution pattern of syndromes in advanced colon cancer in Sichuan.(2)Analysis of the correlation between traditional Chinese medicine syndromes of advanced colon cancer in Sichuan and the general conditions of the patients,the degree of tumor differentiation and the location of the tumor lesions,and thus provide an objective basis for the clinical diagnosis and treatment of advanced colon cancer.Methods: By reading a large amount of literature and clinical data,the "Observation Syndrome Observation Table for Patients with Advanced Colon Cancer in Sichuan Province" was developed to collect the oncology departments of Sichuan Provincial Chinese Hospital from January 2016 to February 2018,which were in line with the inclusion and exclusion criteria of this topic.Patients,collected basic information of patients,four diagnostic information of traditional Chinese medicine,used Excel2016 to establish a database of four information about traditional Chinese medicine for patients,and analyzed the distribution characteristics of syndromes of traditional Chinese medicine and syndromes and patients with advanced colon cancer in Sichuan by statistical methods of cluster analysis.The correlations between the general conditions,the degree of tumor differentiation,and the location of tumor lesions.Results:(1)A total of 226 patients with advanced colon cancer were included,including 131 males and 95 females.The ratio of males and females was 1.38:1.The minimum age was 22 years and the maximum age was 90 years.226 patients were included.The average age was(59.13±15.94)years.The age range of the most patients was 61-70 years old,a total of 63 cases,accounting for 27.9% of the totalnumber of cases;44 cases of smoking patients,accounting for 19.5%,38 cases of drinking alcohol patients,16.8% of the total cases;the clinical stage is mostly stage IV patients,accounting for 68.2% of the total number of cases;pathological type is predominantly adenocarcinoma,accounting for 55.8% of the total number of cases;the degree of tumor differentiation with multiple differentiation See,accounting for31.9%;tumor lesions are more common in the sigmoid colon,accounting for 34.5%;surgical treatment of 163 patients,accounting for 72.1% of the total number of cases.(2)In the frequency distribution of four consultations for patients with advanced colon cancer in Sichuan,mainly due to fatigue(50.4%),lack of appetite for nausea(42.0%),abdominal pain(38.5%),and greasy(38.1%),Head body weight(36.7%),nocturia(33.6%),shortness of breath(31.9%),abdominal distension(29.2%),weak waist and knees(28.3%),less gas lazy speech(28.3%),frequent urination(25.7)%),urine clear(25.2%),loose stool(25.2%),chest tightness(24.3%),aversion to coldness(23.9%),greasy(48.2%),moss yellow(47.8%),moss white(41.6%),large tongue(41.2%),toothed tongue(32.3%),pulse string(31.9%),pulse depth(27.9%),pulse slip(27.4%),pulse(23.9%),pulse Astringency(22.1%)occurred frequently.(3)According to the results of cluster analysis and the combination of expert expertise,the syndromes of TCM in advanced colon cancer in Sichuan were eventually classified into 6 categories: spleen-kidney yang deficiency(27%)and spleen deficiency wet-sheng syndrome(20.8%).),Qi deficiency syndrome(14.6%),qi stagnation and blood stasis syndrome(14.6%),damp heat accumulation syndrome(15.0%),liver and kidney yin deficiency syndrome(8.0%).(4)The TCM syndrome pattern of advanced colon cancer in Sichuan area was significantly related to the age of patients,drinking history,pathological types of tumors,tumor differentiation,site of tumor lesions,and surgical treatment(P<0.05);There was no significant correlation between gender,tumor family history,clinical stage,tumor pathological type and tumor metastasis(P>0.05).Conclusion:(1)Among the patients with advanced colon cancer in Sichuan,there are more men than women,and the middle-aged and the elderly are the main disease groups.Surgical treatment is still the most important and most basic treatmentmethod for patients with advanced colon cancer.(2)Humidity,spleen deficiency,and yang deficiency are the most important pathogenesis factors of advanced colon cancer in Sichuan.Its pathogenesis is "inside and outside wet and disease" and "yang deficiency is yin disease."(3)Among the patients with advanced colon cancer in Sichuan,the young patients were more likely to be empirically tested.The middle-aged patients mostly had evidence of virtual inclusions.The elderly patients had more deficiency syndromes,while the spleen and kidney yang deficiency and spleen deficiency wet throughout the advanced colon cancer.In the age group,as the age increases,the number of patients with deficiency of qi and blood is significantly increased.(4)The degree of malignancy of colon cancer was high in the damp heat accumulation syndrome and qi stagnation and blood stasis syndrome,and the degree of malignancy of the remaining syndromes was relatively low.(5)The left colon was diagnosed with multiple main evidences.The right colon had more common symptoms of deficiency syndromes and false inclusions.The surgically treated patients with advanced colon cancer were mainly syndromes with deficiency syndromes and false inclusions.