| Objective:To establish and standardize the TCM syndrome differentiation classification of obstructive sleep apnea hypopnea syndrome(OSAHS),and explore the correlation between every TCM syndrome and serum superoxide dismutases(SOD),malondialdehyde(MDA).Methods:Adopting the Guidelines for the Diagnosis and Treatment of Obstructive Sleep Apnea Hypopnea Syndrome(Revised 2011)as diagnostic criteria,which was developed by the Chinese Medical Association Respiratory Diseases Branch of Sleep and Respiratory Disorder;Using the 1997 People's Republic of China standard "Chinese medicine clinical diagnosis and treatment of syndrome"(GB/T16751.2.1997)as the diagnostic criteria of TCM syndromes.Selecting 121 OSAHS patients as the study subjects,collecting 79 symptoms,signs,tongue pictures and pulse conditions,testing the corresponding clinical monitoring indexes,putting them in SPSS 20.0 software to establish relevant database,clusting the data of OSAHS patients by means of classify analysis,and summarizing the TCM syndrome classification of OSAHS.Applying Kruskal-Wallis H test and Spearman method of SPSS20.0 software to investigate the relationship between the TCM syndromes of OSAHS and the monitoring indexes of serum SOD,MDA and related PSG.Results:1.The study collected 121 cases of OSAHS patients,78 males,accounting for 64.5%;43 females,accounting for 35.5%.The youngest was 19 years old,the oldest was 75 years old,the average age was 48.22±9.63 years old.2.The cluster analysis results can be identified as Phlegm heat accumulation syndrome,phlegm-dampness syndrome,phlegm and blood stasis syndrome,qi deficiency phlegm stasis syndrome,lung spleen deficiency syndrome,of which the largest proportion of phlegm-dampness resistance was 28.10%,followed by phlegm and blood stasis,Phlegm heat accumulation syndrome,qi deficiency phlegm stasis syndrome,they were 24.79%,20.66%and 16.53%respectively,the proportion of lung spleen deficiency syndrome the lowest,accounted for 9.92%.The syndrome can be classified into three categories:Sthenic Syndrome,Deficiency Symptom and Symptom of Deficiency and Excess,among which 89 cases were Sthenic Syndrome(accounting for 73.55%),and the other was Symptom of Deficiency and Excess(accounting for 16.53%),there were only 12 cases is Deficiency Symptom(accounting for 9.92%).3.The Epworth Sleepiness Scale(ESS)score of Phlegm heat accumulation syndrome was the lowest in the syndrome group(P<0.05)4.LSaO2 of Phlegm heat accumulation syndrome was higher than phlegm and blood stasis syndrome,Qi deficiency and phlegm stasis syndrome,lung spleen deficiency syndrome,spleen deficiency syndrome LSaO2 1 was the lowest in the syndrome group(P<0.05).5.The Phlegm heat accumulation syndrome and phlegm-dampness of SOD was higher than the level of phlegm and blood stasis syndrome,Qi deficiency and phlegm and blood stasis,while the level of MDA was lower than that of phlegm and blood stasis syndrome,Qi deficiency and phlegm and blood stasis,lung spleen deficiency syndrome,lung spleen deficiency syndrome was the lowest in the SOD group(P<0.05).6.In comparison with the severity of OSAHS and TCM syndrome type,the severity of phlegm-damp syndrome and Deficiency of qi and phlegm and dampness sydrome tend to be mild and moderate.while the syndrome of intermin-gled phlegm and blood stasis,and qi deficiency and phlegm stagnation syndrome tend to be moderate and severe.Lung and spleen deficiency syndrome mostly tend to be severe.7.There was negative linear correlation between the severity of OSAHS and SOD(rs=-0.716,P<0.05),while positive linear correlation between it and MDA(rs=0.560,P<0.05).Conclusion:1.TCM OSAHS divided into five types through classify analysis,they were phlegm heat accumulation syndrome,phlegm-dampness syndrome,phlegm and blood stasis syndrome,Qi deficiency and Phlegm Blood Stasis Syndrome,lung spleen deficiency syndrome,which is the second empirical,deficiency syndrome of intermingled deficiency and excess,relatively less.2.Most patients of Phlegm-damp syndrome and Deficiency of qi and phlegm and dampness sydrome are OSAHS patients,who are not so serious.but the severity of the syndrome of intermin-gled phlegm and blood stasis,and qi deficiency and phlegm stagnation syndrome are mostly moderate and grievous.Lung and spleen deficiency syndrome tend to be quite severe.3.It can be found in the MDA and AHI of phlegm heat stasis,phlegm,phlegm and blood stasis syndrome,Qi deficiency and Phlegm Blood Stasis Syndrome,Qi deficiency of lung and spleen were increased in turn;in the SOD,the LSa02 of phlegm heat stasis,phlegm,phlegm and blood stasis syndrome,Qi deficiency and phlegm and blood stasis,Qi deficiency of lung and spleen in turn to reduce the severity of SOD;The level of SOD and MDA may indicate the severity of the disease,which can provide reference value for the differentiation of symptoms and signs of OSAHS. |
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