Research On Logic Calculation Model Based On Ion-induced Molecular Self-assembly And Chain Replacement Technology

With the rapid development of computer, the computer's physical devices have obtained fast development, the function is richer and richer, the price is cheaper and cheaper, and its volumes are shrinking. The development of computer has experienced four different times, from the first generation to the fourth generation are respectively with vacuum tube, transistor, integrated circuit and large scale integrated circuit as the main components of the computer. However, in recent years, the rise of molecular computer with the Nano-sized nucleic acids as research materials further strengthen the computer's operation speed by the ability of parallel computing. What's more, the molecular computer with the size of the nanoscale is able to store large amounts of useful information, and an upsurge of research is setting off in the field of computer gradually. And the molecular computer application field is also very wide, which can continuously applied to computer science, life science, biology, physics, biochemistry and applied mathematics and many other fields.In this paper, we first introduced the research background of ion-induced molecular self-assembly, domestic and foreign research present situation and development trend, and the basic principles used in the ion-induced molecular self-assembly were introduced in detail, such as the strand displacement technology, ion-induced structural transformation and the special cation can bind to the same base pairs. Most important was that we not only drew a conclusion about the relevant principle and application, but also constructed multiple logical calculation model. Its first logic gate (INH) made use of H+-induced structure transformation combining with DNA/RNA strand displacement technology. However, the successful implementation for the following OR, AND, cascade circuit and signal amplifier were use of the special cation stably bind to the particular base pairs with the strand displacement. In this paper, the detailed distribution was as follows:(1) In this article, we first carried on the detailed elaboration about the molecular self-assembly, while the mechanism of ion-induced molecular structure transformation is belong to molecular self-assembly. Therefore, here, we only discussed the research background and significance about ion-induced molecular self-assembly, and described the research on the status quo and the trend of development for the subject in detail.(2) In this paper, we mainly summarized the development of ion-induced the molecular self-assembly in the second chapter, and explained the principle of ion-induced molecular structure transformation and special ion could bind to the same base pairs. Above the two kinds of principle, we mainly illustrated how to apply with the acid and alkali ions and some special metal cation in the logic calculation model. It seemed that ion-induced molecular self-assembly would develop better and better in the future.(3) The third chapter of this paper built an INH logical gate models combining the H+ and OH" induced molecular self-assembly with the strand displacement technology. However, all above the models could be used to detect on the environment, the governance of water pollution, disease diagnosis and so on. In our experiments, we used NUPACK for designing strand-sequences and Visual DSD software for simulation. The construction of these models provided a new and feasible scheme for the next step to research with saving the experimental materials and it was easy to control at the same time. In fact, it was of great theoretical and application value.(4) What studied in the fourth chapter was that a unimolecular multifunctional DNA cascaded logic circuit and signal amplifier based on Hg2+ and Ag+ was designed in this paper. Its successful design had a connection with Hg2+ and Ag+ could two same base pairs and stabilized T-T and C-C mismatch in DNA duplex through T-Hg2+-T and C-Ag+-C interaction respectively.(5) The fifth chapter of this article had mainly made a simple summary and outlook about this research topic. Looking forward to the research based on ion-induced molecular self-assembly would be more and more popular in the near future, and could be further applied in medicine, biology, physics, biochemistry, mathematics and many other fields.