Guo Zhiqiang Clinical Observation Of Sequential Therapy For DOR Combined With Thyroid Antibody Positive

ObjectiveExperiment l:To explore the correlation between DOR and TPOAb?TGAb throug h cases data retrospective study,also discuss the effects of age,TSH and adverse pre gnancy history on it.Experiment 2:To observe the clinical efficacy including both OR and immunity fi eld of TCM sequential therapy of professor Zhiqiang Guo in treating DOR associated with TPOAb and TGAb,also search the effect when use Euthyrox simutaneously.MethodsExperiment 1:Collect 425 cases whose reports of female hormone and TPOAb?T GAb at the first clinical time are complete and also eliminate ones with other potentia 1 disease causes.Record if their reports including TSH are abnormal and the age?adve rse pregnancy history.Experiment 2:Pick out 40 cases without contraception from experiment 1 who are DOR associated with TPOAb and TGAb,TSH ranges between 2.5-4.9uIU/mL and do the clinical observation.Divide the patients into two groups of each includes 20 patie nts by different treatments of using TCM alone or applying Euthyrox simultaneously.Monitor the TSH during the therapy and compare the efficacy of female hormone,thy roid antibodie,pregnancy and sympotoms between and within groups after 3 months t herapy.ResultsExperiment 1:(1)There are 83 patients who are DOR associated with either a ntibodie,104 DOR with neither antibodie patients,30 normal ovary function associated with either antibodie patients and 208 normal ovary function with neither antibodie pat ients Among the 425 cases.lt proves there is significant correlation between DOR and TPOAb?TGAb.(P<0.05).(2)The quantity of DOR with neither antibodie patients varies with the growth of age,especially begins at 35,while DOR associated with either antibodie patients did not vary apparently with age and tended to decline after 38years old.(3)There is no significant correlation between normal and abnormal TSH patient s in the four groups.(4)There is significant correlation between DOR and adverse pr egnancy history(P<0.05).(5)There is no significant correlation between thyroid antibodie and adverse pregnancy history(P>0.05).Experiment 2:(1)There were 50%cured patients in TCM with Euthyrox group while 30%in the other.However,there is no significant difference(P<0.05),and the total effective rate between groups are the same.(2)TCM group shows significant efficacy in FSH and E2(P<0.05)while the other group does in FSH/LH and E2(P<0.05).TCM group shows no significant efficacy in FSh/LH(P>0.05)while the other does not in FSH(P>0.05),there is significant difference between groups in therapy of FSH and FS H/LH(P<0.05).There is no significant difference between groups in therapy of E2(P>0.05).(4)Four patients got good pregnant condition in TCM with Euthyrox group and fo ur got adverse pregnant during the observation while the other group got no good pre gnant condition patients but four adverse pregnancies.There is no significant differenc e between groups in rate of pregnancy(P>0.05)but significant difference in rate of ad verse pregnancy(P<0.05).(5)Both groups shows no significant improvement in menstrual cycle,tidal fever,dizziness and tinnitus,P>0.05 between and within groups.There is s ignificant improvement in hypomenorrhea,soreness and weakness of lumbar and knee region,insomnia and dreaminess within each group after therapy(P<0.05)while no signi ficant difference between the groups(P>0.05).The TCM with Euthytox group shows bet ter improvement than the other in sexual hypoactivity(P<0.05).ConclusionsExperiment 1:(1)There's significant correlation between DOR and TPOAb?TGAb,meanwhile did not completely affected by age.lt may more likely be age growth theco use of DOR without antibodies.,women should care about maintenance of ovary funct ion since 35.(2)As TSH was analyzed at the critical level of 4.91uIU/mL,TPOAband TGAb did not affect ovarian function by way of TSH(3)DOR induces adverse pregnan cy,but may not by the effect of TPOAb and TGAb.Experiment 2:(1)The level of FSH,FSH/LH and E2 can be diminished significan tly with the treatment of TCM sequential therapy of professor Zhiqiang Guo in DOR patients with thyroid antibodies.(2)The Chinese medicine can significantly improve the rate of pregnancy and antibody conversion among the patients and almost nothing to do with Euthyrox,However,Euthyrox can significantly improve the efficacy of Chines e medicine on rate of adverse pregnancy.(3)Professor Guo's therapy can significantly i mprove hypomenorrhea,soreness and weakness of lumbar and knee region,insomnia an d dreaminess,irritability,less leucorrhea,tiredness,cold feeling on lumbar and abdome n and almost nothing to do with Euthyrox,however,the TCM with Euthytox group ca n improve sexual hypoactivity better than the other.In conclusion,thyroid antibodies are much related to DOR.By statistical analysis of the influence of TSH over it and Euthyrox almost did nothing in ovarian function improvement,there may be other ways for thyroid antibodies to affect ovarian functio n.DOR can highly induce adverse pregnancy,by statistical analysis of the influence oft hyroid antibodies over it and considering Euthyrox can significantly improve the rate of adverse pregnancy but did nothing with antibodie conversion,thyroid antibodies ma ynot involved adverse pregnancy cause of DOR.The Chinese medicine therapy of Pro fosser Guo can surely improve DOR patients with TPOAb and TGAb in respects of o vary function,symptom,rate of pregnancy and immunity environment.But as a critical reminder,in the process of Chinese medicine therapy on threatened abortion patients,E uthyrox can not be ignored.