The Effect Of Air Pollution On Lung Function And Quality Of Life In Adult Asthma Patients

Background The effects of air pollution on chronic respiratory diseases is drawing increasing attention.There are large amount of epidemiologic studies focus on the morbidity and acute exacerbation of asthma caused by air pollution.However,more evidence about the impact of air pollution on the health-related quality of life and pulmonary function is necessary.Object This study is to analyze the relationship between air pollution and health-related quality of life and pulmonary function in adult asthma.Method In this study,we recruited 62 asthma participants in Beijing,China.All subjects finished the general information,pulmonary function test and the questionnaire of asthma quality of life questionnaire?AQLQ?,short form 36-item health survey?SF-36?,asthma control test?ACT?,physical activity rating scale-3?PARS-3?.The estimation of air pollution exposure was based on the address of home and office.Spearman correlation analysis was used to estimate the relationship between particulate matter ?2.5?m in aerodynamic diameter?PM2.5?,particulate matter?10?m in aerodynamic diameter?PM10?,ozone?O₃?,sulfur dioxide?SO₂?,nitrogen dioxide?NO₂?,carbon monoxide?CO?and health-related quality of life,pulmonary function of participants.Results The increase of O₃ was associated with the decrease of SF-36,AQLQ;The increase of PM2.5?PM10?SO₂?NO₂?CO was associated with the increase of SF-36,AQLQ;The increase of NO₂ was associated with the increase of ACT;The increase of PM10?PM2.5?SO₂?CO was associated with the decrease of FEV1/FVC;The relationship between air pollution and PARS-3 was weak.Conclusion O₃?NO₂?CO make an impact on the health-related quality of life and PM2.5?PM10?CO make an impact on the pulmonary function of asthma patients.Gender,smoking habit,drug used,and COPD overlap may cause the heterogerity of effects.BackgroundThe effects of air particulate matter pollution on the pulmonary function of healthy people and asthma patients had been proved by many studies.However,evidence about the impact of exposure of particulate matter<10?m in aerodynamic diameter?PM10?on the pulmonary function of asthma adults is not sufficient.ObjectiveThis study is to illuminate whether the exposure of particulate matter?10?m in aerodynamic diameter?PM10?has an impact on the lung function in adult patients with asthma.Method17 asthma adults from inhabitants of Beijing were recruited and followed for 9 months,during which time they received at least two tests of spirometry every three months.We got 26 corresponding data of spirometry test at the beginning and the end of 3 months period.We analyzed the association between the variation of lung function in three months and the average exposure of PM10 during the corresponding period.The six lung function parameters used for analysis were pre-bronchodilator forced expiratory volume in 1 second expressed as percent predicted?Pre FEV1%?,pre-bronchodilator forced vital capacity?Pre FVC%?expressed as percent predicted,pre-bronchodilator FEV1/FVC?Pre FEV1/FVC?,post-bronchodilator FEV1 expressed as percent predicted?Post FEV1%?,post-bronchodilator FVC expressed as percent predicted?Post FVC%?,post-bronchodilator FEV1/FVC?Post FEV1/FVC?.The changes of these parameter during the observation period were respectively defined as APre FEV1%??Pre FVC%??Pre FEV1/FVC?APost FEV1%??Post FVC%??Post FEV1/FVC.The discrepancy between lung function and PM 10 exposure is examined by independent-samples t test or nonparametric rank-sum test.ResultDuring three months of the observation period,the participants were divided into the relatively higher PM10 exposure group[?98.00�10.99??g/m3,n=13]and relatively lower PM10 exposure group[?79.23�6.30??g/m3,n=13]based on the median value.Compared with the relatively lower PM 10 exposure participants?the four variation was responsively 4.32�12.02,2.22�5.38,7.61�12.66,6.54�7.93?,the ?Pre FEV1%,?Pre FEV1/FVC,and ?Post FEV1/FVC of participants with relatively higher PM10 exposure?the four variation was responsively-6.96�10.49,-3.79�7.92,-4.07�5.72,-2.92�5.14?showed significant reduction?P<0.05?.The ?Pre FVC%?the variation was responsively-4.62�8.83,2.63�13.49?,APost FVC%?the variation was responsively-2.65�6.74,0.28�13.58?)presented a downtrend in participants with relatively higher PM10 exposure but fail to reach a significant level.ConclusionThis study suggested that the long term PM 10 exposure has a negative effect on the pulmonary ventilation function of asthma adults.Further investigations are required.