Study On Comparison Of Executive Function Between Patients With Obsessive-compulsive Disorder And Obsessive-compulsive Personality Disorder

Object Obsessive-compulsive disorder(OCD)is a psychiatric disorder featured as obsessive thoughts and compulsive behavior,obsessive-compulsive personality disorder(OCPD)is a psychiatric disorder characterized by focusing on detail,perfectionism as well as controlling interpersonal relationship at the expense of flexibility,openness and efficiency.Although obsessive-compulsive disorder and obsessive-compulsive personality disorder are separate psychiatric disorders in DSM-V,their core symptoms are partly same,that leads to be difficult to distinguish these two disorders.At present,executive function is a key and hot spot in cognitive nueropsychological study.There were a lot of studies about executive function,which showed that impaired executive function was found in most psychiatric disorders including obsessive-compulsive disorder and obsessive-compulsive personality disorder.Hence,we will use cognitive neuropsychological tests combining with event related potential technology to explore the difference of executive function between obsessive-compulsive disorder and obsessive-compulsive personality disorder,for supplying some electrophysiological evidences for the relationship between them.Methods In study one,using Wisconsin card sorting test,Iowa gambling task,game of dice test to test cognitive flexibility and decision function in 31 OCD patients,33 OCPD patients and 33 healthy controls(HC).Three groups are age-,sex-,education-matched.In study two,using stop signal test combining with event related potential technology to test response inhibition in 21 OCD patients,20 OCPD patients and 20 HC,as well as recording subjects’ data by Neuroscan ERP equipment.Three groups are age-,sex-,education-matched.Results In study one,the OCD patients have higher total errors,perseverative responds and perseverative errors in WCST than OCPD patients and HC(P<0.05).And in IGT,the OCD patients’ and OCPD patients’ block3 scores,block4 scores and total net-scores(P<0.01)are lower than HC.Using one-way anova analysis to respectively analyze three groups’ decision course,showing that differences among different blocks in OCPD patients(P<0.05)and HC(P<0.01)were significant.Block3 to block5 in OCPD patients were higher than block1(P<0.05),Block2 to block5 in HC were higher than block1(P<0.01).Different blocks in OCD patients were not significant.There were no differences in GDT among three groups(P>0.05).In study two,GORT in OCD patients and OCPD patients were longer than HC(P<0.01).SSRT in OCD patients was longer than OCPD patients(P<0.05).There were no difference of N2 amplitudes among three groups.N2 latency in OCD patients was shorter than HC(P<0.05).Go-P3 amplitudes in OCD patients were larger than OCPD patients and HC in F3,F4,FZ,C3,C4,CZ(P<0.05).Stop-P3 amplitudes in OCD patients were larger than OCPD patients and HC in F4,FZ,C3,CZ,P3(P<0.05).There were no differences in P3 latency among three groups(P>0.05).Conclusions In study one,cognitive flexibility of OCPD patients was worse than OCPD patients and HC,both of them had impaired decision functions under ambiguity,but their decision models are different.Their decision functions under risk were intact.In study two,respond inhibition of OCD patients was worse than OCPD patients.Stop-P3 in OCD patients,OCPD patients and HC are different.