Clinical Observation On HuangWuTeng Lotion Prevention Of Cold Dampness And Blood Stasis Type For Chronic Peripheral Nerve Toxicity Caused By Chemotherapy

Objective:The study was designed to observate and evaluate the clinical effects of Huang Wu Teng Lotion prevented from Cold dampness and blood stasis type for Chronic peripheral nerve toxicity caused by chemotherapy and explore its possible mechanism in order to guide the treatment of peripheral nerve injury caused by chemotherapy.Methods:44 cases of gastric or colorectal cancer patients acceptted of chemotherapy by FOLFOX4or FOLFOX6.from June 2014 to June 2016 were randomly divided into the experiment group and the control group?n=22?,the experiment group received the treatment of Huang Wu Teng Lotion combined with Mecobalamin,the control group received Mecobalamin alone.Observed the clinical symptoms of TCM,score of activities of day living,sensory nerve conduction velocity,incidence of peripheral nerve toxicity andother indicators.Rusults:?1?Aspects of clinical symptom:Peripheral nerve toxicity accompany with deterioration in the cold has numb limbs as the main symptom and systemic symptoms associated with cold dampness and blood stasis and related lingual arteries and veins.The experiment group's incidence of symptoms with cold dampness and blood stasis is below the control group.It illustrated that Huang Wu Teng Lotion could prevent from the peripheral nerve toxicity with the type of cold dampness and blood stasis in oxaliplatin.?2?Quality of life:There were no significant differences in the ADL scorebefore receiving treatment?P>0.05?;compared with the control group,ADL score in experiment group with 8and 12 Cycles of chemotherapy was higher that the differences were statistically significant(P^?<0.05,P^??<0.05);It prompted that Huang Wu Teng Lotion combined with Mecobalamin was better than the single application of Mecobalamin in improving the quality of peripheral nerve toxicity in L-OHP.?3?Peripheral sensory nerve conduction velocity?median nerve?:There were no significant differences about conduction velocity before receiving treatment and with4 Cycles of chemotherapy?P>0.05,P^??0.05?;Conduction velocity in experiment group with 8 and 12 Cycles of chemotherapy wasFaster than the control group that the differences were statistically significant(P^??<0.05,P^???<0.05);It testified that Huang Wu Teng Lotion combined with Mecobalamin was better than the single application of Mecobalamin in treating peripheral nerve toxicity in L-OHP and the peripheral nerve toxicity before the first 4cycles of chemotherapy?cumulative toxic?340mg/m²?is not serious.?4?The cumulative dose of Chronic peripheral nerve toxicity in L-OHP:The emergence of the chronic toxicity of peripheral nerve in control group is sooner than the experiment group that the differences were statistically significant?P<0.05?;The maximum level is 680mg/m² in experiment group and 340mg/m² in control group.It illustrated that Huang Wu Teng Lotion can reduce the incidence and delay the toxic degree of peripheral nerve toxicity.?5?The incidence of peripheral nerve toxicity:The incidence of peripheral nerve toxicity with8 and 12 Cycles of chemotherapy showed that the differences were statistically significant?P<0.05?P^?<0.05?;It prompted that Huang Wu Teng Lotion can reduce the incidence.?6?Classification in NCI:Grades-1-and-2-toxicity of peripheral nerve's appearance had statistically significant differences?P<0.05?P^?<0.05?,and the Grades-1-2-and-3-toxicity of peripheral nerve's cumulative dose of L-OHP in experiment group is higher the control group,It turned out that Huang Wu Teng Lotion not only can reduce the degree but also delay the progress of toxicity.?7?The incidence of unable to withstand the nerve damage in control group is higher that leveled that Huang Wu Teng Lotion can improve the symptoms and ensure the normal conduct of chemotherapy.Conclusion:HuangWuTeng Lotion can prevent the peripheral nerve toxicity with the type of cold dampness and blood stasis in oxaliplatin,improve the sensory nerve conduction velocity of chronic accumulation toxicity in electromyography,ADL scores and other objective indicators,induce the incidence of peripheral nerve toxicity,improve the symptoms of peripheral nerve toxicity and ensure the normal conduct of chemotherapy.