The Incidence And Effect Factors Of Gallstone

Objectives To investigate the incidence and effect factors of gallstone.Methods This is a prospective cohort study to observe the incidence of gallstone.A total of 101,510 in-service and retired employees of the Kailuan Group who took part in the first round of physical examination in the year 2006?2007 were subjects of the research for follow-up investigations and observation of incidence of gallstone.Uniform questionnaire survey,blood biochemical tests and abdominal ultrasound examination were conducted on the subjects.In the end,82,341 participant cases were included in the statistical analysis.Kaplan-Meier method is used to calculate incidence of gallstone,which is then tested using log-rank test for differences in incidences of gallstone among different gender and age groups.Cox proportional hazards model is used to analyze effect factors of gallstone.Results 1 Over a mean follow-up period of 5.52±1.40 years,among the 82,341 participants,1,846 developed gallstone during the follow-up period,including 1,434 male and 412 female.The overall incidence of gallstone was 2.2%(male: 2.2%,female: 2.3%).2 After using the Multiple Cox Proportional Hazard Regression Analysis,increased age(40-60 years versus<40 years,HR=1.95[95% CI 1.63?2.33],?60 years versus<40 years,HR=3.34[95% CI 2.75?4.06]),BMI(24-28kg/m2 versus < 24kg/m2,HR=1.33[95% CI1.19?1.49],?28kg/m2 versus < 24kg/m2,HR=1.49 [95% CI 1.30?1.71]),diabetes(yes versus ideal fasting glucose,HR=1.17 [95% CI 1.01?1.36]),hs CRP(0.80-2.10mg/L versus<0.30mg/L,HR=1.22[95% CI 1.06?1.42],?2.10mg/L versus<0.30mg/L,HR=1.48[95%CI 1.28?1.70]),drinking(yes versus no,HR=0.87[95% CI 0.77?0.99]).Conclusions The incidence of gallstone is increased with age,blood pressure,BMI,and fasting blood glucose.Increased age,high BMI,diabetes,and high hs CRP are risk factors of gallstone,and moderate level of alcohol drinking is a protective factor in terms of incidence of gallstone.