Effect Of Infantile Eczema On Growth And Development In Infants

Objective:To understand the present situation of infantile eczema and to explore the influencing factors of infantile eczema;and to analyze the effect on the infant's physical development,cognitive development and the blood level of 25-?OH?-VitD₃.Methods:According to the principle of"informed consent and voluntary",there were1135 infants,with the age of about 1 month,6 months and 12 months,selected randomly from the children's health care clinic in a level III hospital of Suzhou city.The questionnaire has been conducted on these infants'parents,to record the potential related factors of infantile eczema.Among them,267 infants were followed up from 1 month old to 12 months old,and the physical development of them have been recorded at 3 months,6months,8 months and 12 months respectively.The Bailey children's Development Scale III cognitive subscale of them has been finished by the trained practitioner.Chi-square test and Logistic regression analysis were used to analyze the related factors of infantile eczema,and the methods of T test and continuous repeated measurement of variance analysis were used to analyze the effect of infantile eczema on their physical development,cognitive ability and blood level of 25-?OH?-VitD₃.Result:?1?The prevalence rate of infantile eczema in 1 month old,6 months and 12months was 59.1%,41.7%and 19.8%respectively.The difference was statistically significant?P<0.05?.?2?After single factor analysis and screening,infantile eczema was related to delivery mode,feeding pattern,baby care products and outdoor activity time?P<0.05?.The results of Logistic regression analysis showed that artificial feeding?OR=1.586,95%CI1.219-2.063,P<0.05?and mixed feeding?OR=2.824,95%CI 1.909-4.178,P<0.001?were risk factors of infantile eczema.Cesarean section?OR=0.655,95%CI 0.504-0.850,P<0.05?,outdoor activities from 1 to 2 hours?OR=0.282,95%CI 0.166-0.479,P<0.001?,2 hours of outdoor activities for more than 2 hours?OR 0.489,95%CI 0.35-0.682,P<0.001?and the use of baby care products?OR=0.775,95%CI 0.606-0.992,P<0.05?were protective factors of infantile eczema.?3?The effect of infantile eczema exists on the development of length,weight and head circumference.?4?Eczema has no significant effect on infants'cognitive development.?5?There is no significant effect on the blood level of 25-?OH?-VitD₃.Conclusion:?The incidence of infantile eczema decreased with age,and it was a way of discharge of"toxicity".?Breastfeeding,appropriate outdoor activities and use of proper baby care products were the protective factors to reduce the incidence of infantile eczema.?Metabolism is an important factor in the occurrence of infantile eczema,and the balance of Th1/Th2 tends to ease eczema.?Infantile eczema can affect the baby's development of length,weight and head circumference,without significant effect on the content of 25-?OH?-VitD3.