| ObjectiveStudying how blood stasis syndrome infects OP and the correlation between objective test index of blood stasis syndrome and Biochemical markers of bone metabolism,to evaluate the severity of osteoporosis,and to provide a method for further prevention and treatment of primary osteoporosis.MethodsAccording to the clinical experience of geriatrics Xiyuan Hospital professor Li Yuehua more than 30 years,the patients in the Department of Geriatrics,Xiyuan Hospital outpatient and inpatient patients with primary osteoporosis,a total of 500 cases,using the method of epidemiological survey statistics,questionnaire survey,record the degree of pain points,bone density measurement T value,blood testing objective metabolism index of blood stasis syndrome and bone biochemical markers,and record the results.The 500 patients were divided into liver and kidney deficiency,spleen and kidney two empty,spleen and kidney deficiency and blood stasis two three syndromes.Comparison between these three kinds of osteoporosis syndromes,age,gender,osteodynia integral value,T value of BMD,fracture incidence,blood stasis index and bone metabolism index relationship standard.All selected cases using statistical software to test data analysis,observation of the relationship between blood stasis syndrome objective index and bone metabolic biochemical markers,and draws a conclusion.Result1.The majority of patients with primary osteoporosis were female,and the sex ratio was about 1:4.4.2.500 cases of patients,40-49 years old accounted for 2.2%,50-59 years old accounted for,60-69 years old accounted for 33%,70-80 years old accounted for 50.4%,This suggests that osteoporosis is characterized by degenerative disease that increases with age and increases the risk of disease.3.500 cases of patients with primary osteoporosis,liver and kidney deficiency,spleen and kidney deficiency syndrome,spleen and kidney deficiency and blood stasis syndrome accounted for three of the total number of 15%?21.8%?63.2%.Thus it can be seen that the highest license type of primary osteoporosis is the deficiency of the spleen and kidney and the blood stasis syndrome in two cases.4.From the above three types of syndromes,with the growth of age,the incidence of osteoporosis has increased,Among them,spleen and kidney two virtual and blood stasis syndrome were the most in the age stratification.5.The bone mineral density of the liver and kidney deficiency syndrome was-2.944±0.574.The bone mineral density of the spleen and kidney deficiency syndrome was-3.158±0.554.The bone mineral density of the spleen and kidney was-3.876±0.958.The T value of bone mineral density(BMD)was the lowest in two patients withdeficiency of spleen and kidney and blood stasis,and had the most severe incidence of osteoporosis.6.Spleen and kidney two deficiency syndrome,deficiency of liver and kidney syndrome,spleen kidney deficiency and blood stasis syndrome of the three types of syndrome of the integral value of the pain,were 9.86±2.67,10.09±3.53,13.32±2.98.Among them,two cases of spleen kidney deficiency and blood stasis syndrome of the highest value of bone pain,indicating that the most severe symptoms of bone pain.7.Of the 500 patients,there were a total of 143 patients who had a history of fracture or a hospital visit,accounting for 28.6%.The incidence of the three types of fracture:liver and kidney deficiency syndrome was 3.49%,spleen and kidney deficiency syndrome was 13.99%,kidney and spleen deficiency and blood stasis syndrome was two 82.52%.Deficiency of spleen and kidney with blood stasis syndrome is the cause of high incidence of fracture due to osteoporosis syndrome type two.8.Endothelin,thromboxane,prostacyclin and other indicators of blood stasis and bone formation markers osteocalcin,bone alkaline phosphatase,Procollagen Type? C-terminal Propeptide(1)The correlation coefficient between endothelin and bone alkaline phosphatase is r =-0.538;and the correlation coefficient between endothelin and osteocalcin is r =-0.652,,the correlation coefficient and propeptide of procollagen type ? carboxy terminal is r =-0.543;(2)The correlation coefficient of thromboxane and bone for alkaline phosphatase is r =-0.593;and the correlation coefficient of thromboxane and osteocalcin is r =-0.615;the correlation coefficient and propeptide of procollagen type ? carboxy terminal is r =-0.419;(3)The correlation coefficient of prostacyclin and bone alkaline phosphatase is r= 0.311;and the correlation coefficient of prostacyclin and osteocalcin is r = 0.497;the correlation coefficient and propeptide of procollagen type ? carboxy terminal is r= 0.341.9.Blood stasis syndrome index of endothelin,thromboxane,prostacyclin and bone resorption markers of acid phosphatase,correlation of type ? collagen cross-linked carboxy terminal peptide:(1)The correlation coefficient between endothelin and acid phosphatase is r =0.524;and the correlation coefficient between endothelin and ? collagen cross-linked carboxy terminal peptide is r = 0.488.(2)The correlation coefficient between thromboxane and acid phosphatase is r =0.434;and the correlation coefficient of thromboxane and ? type collagen cross-linked carboxy terminal peptide is r = 0.637.(3)The correlation coefficient of prostacyclin and acid phosphatase is r =-0.308;the correlation coefficient of prostacyclin and ? type collagen cross-linked carboxy terminal peptide is r =-0.373.ConclusionThe possibilities of OP is increasing by ages and gender,and it is a disease with high age.The deficiency of the kidney is the basic pathogenesis of OP,with the deficiency of the blood stasis and the number of involved organs,the incidence of osteoporosis.As to the primary OP,it is most possible for a patient to have deficiency of kidney and spleen and blood stasis.The deficiency of spleen is an important motivator of OP and makes the patient suffer more.Deficiency of spleen and kidney and blood stasis syndrome is the factors of the high incidence of pathological fracture.The patients of the deficiency of kidney and spleen and blood stasis has low T value of BMD,bone pain score high characteristics of incidence.Objective indexes of blood stasis syndrome are negatively positively related to bone reformation indexes,but positively related to bone resorption. |
PDF Full Text Request