Effects Of Compound Sanqi Particles On Clinical Study And Blood Lipid And VWF And VCAM-1 For The Treatment Of Geriatric Coronary Heart Disease Stable Angina Pectoris

Objective:In this study,gerontal patients with stable angina pectoris were treated with compound sanqi particles and Western Medicine.The clinical effect and change of blood lipid,vWF and VCAM-1 levels were observed before and after treatment to investigate the effect of compound traditional Chinese medicine on clinical efficacy and related indexes,and to explore its possible mechanism.Method:According to the diagnostic criteria of coronary heart disease and the diagnostic criteria of TCM syndrome,60 patients with stable angina pectoris of kidney deficiency and blood stasis syndrome were selected and divided into study group and control group randomly(n=30).The control group was given conventional western medicine treatment:aspirin 0.1g,once a day,metoprolol 23.75 mg,once a day,isosorbide mononitrate 20 mg orally,two times a day,atorvastatin 20 mg orally,once a night.On the basis of conventional western medicine treatment,the study group was treated with compound sanqi particles.Drug composition: sanqi 4g,hawthorn 10 g,Salvia miltiorrhiza 10 g,Radix 10 g,Ganoderma 12 g,water decoction,one dose daily,two times a day.Two groups of patients with angina pectoris were given nitroglycerin 0.5mg sublingual,repeated for about 5 minutes,until the pain relief.The two groups were treated for 4weeks.Before and after treatment were observed in two groups of patients with clinical symptoms,TCM syndromes,nitroglycerin stop rate,ECG changes,blood lipids,vWF,VCAM-1 levels.The data were analyzed by SPSS17.0 statistical software.Result:1.In the study group,the total effective rate of angina score,the total remission rate of angina pectoris,the integral of TCM syndrome,the total effective rate of TCM syndrome improvement,and the total effective rate of ECG were better than those of the control group(P<0.05)in Seattle;There was no significant difference between the studygroup and the control group(P>0.05).2.The levels of TC,TG and LDL-C in the two groups were decreased compared with before treatment,the level of HDL-C increased,and the difference was statistically significant(P<0.01);After treatment,compared with the control group,the levels of TC,TG and LDL-C in the study group were significantly lower than those in the control group,and the difference was statistically significant(HDL-C)(P<0.01).3.The vWF levels of the two groups were decreased compared with before treatment,the difference was statistically significant(P<0.05);After treatment,the level of vWF in the study group was lower than that in the control group,and the difference was statistically significant(P<0.01).4.The VCAM-1 levels of the two groups were decreased compared with before treatment,the difference was statistically significant(P<0.01);After treatment,the level of VCAM-1 in the study group was lower than that in the control group,and the difference was statistically significant(P<0.01).5.Comparison of blood routine,liver and kidney function,blood coagulation indexes before and after treatment,there were no significant differences(P>0.05);Patients did not appear due to adverse drug reactions.Conclusion:The clinical efficacy of compound sanqi particles combined with conventional western medicine in the treatment of elderly patients with stable angina pectoris can improve blood lipids,vWF,VCAM-1 levels,suggesting that the combination of traditional Chinese and Western medicine treatment of clinical benefit.The mechanism may be:?Regulate lipid metabolism,reduce lipid deposition,prevent AS.?Inhibit endothelial cell injury,improve endothelial function,prevent AS.