| Objective:Through clinical research,the clinical efficacy and safety of Fufang Sanqi Humai Decoction in the treatment of patients with stable angina pectoris and kidney deficiency and blood stasis in coronary heart disease were observed.The main indicators were serum hs-CRP,fibrinogen,blood lipid,TCM syndrome score,Chinese medicine.Syndrome total curative effect,angina pectoris effect,nitroglycerin cessation rate,electrocardiogram efficacy,etc.,preliminary discussion of its mechanism of action,providing a theoretical basis for the prevention and treatment of coronary heart disease stable angina pectoris.Method:Sixty patients with clinically consistent Western medicine diagnostic criteria for stable angina pectoris and TCM syndrome of kidney deficiency and blood stasis were randomly divided into study group and control group,with 30 cases in each group.The research group is compound Sanqi Humai Decoction(drug composition: Sanqi powder 4g blunt,salvia miltiorrhiza 15 g,Lonicera japonica 15 g,Polygonum multiflorum 15 g,hawthorn 10 g,fried by the preparation center of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine.2 bags,150 ml per bag,1 bag/time,twice daily,warm clothes for half an hour after breakfast and dinner)+ Western medicine for coronary heart disease;control group for Western medicine for coronary heart disease(treatment drug: aspirin 0.1g qd;Metoprolol 23.75 mg,qd;isosorbide mononitrate 20 mg bid;atorvastatin 20 mg qn;nitroglycerin tablets 0.5mg when angina pectoris,sublingual).After treatment,the patient's serum hs-CRP,fibrinogen,blood lipid levels and TCM syndrome scores,TCM syndrome total efficacy,angina pectoris effect,nitroglycerin arrest rate,ECG efficacy,and adverse reactions during treatment were recorded.Evaluate clinical efficacy and safety.Result:1.The improvement of angina pectoris effect: The therapeutic effect of angina pectoris was significantly improved in the study group.The total effective rate was 96.66%,and the total effective rate of the control group was 73.33%.The improvement of angina pectoris was better in the study group than in the control group(P<0.05).2.Improvement of nitroglycerin cessation rate: The nitroglycerin cessation rate of the study group was significantly improved after treatment,the total cessation rate was 90%,and the total reduction rate of the control group was 66.66%.The study group improved the nitroglycerin cessation rate.There was no significant difference compared with the control group(P>0.05).3.improvement of electrocardiogram effect: The electrocardiogram effect of the study group was significantly improved after treatment,the total effective rate was 93.33%,and the total effective rate of the control group was 66.66%.The improvement of ECG effect in the study group was better than that of the control group(P<0.05).4.Improvement of TCM Syndrome Effect: After treatment,the TCM syndromes improved significantly,the total effective rate was 80%,and the total effective rate of the control group was 29.9%.The improvement of the effect of angina pectoris in the study group was better than that of the control group(P< 0.01).5.improvement of TCM syndrome scores: TCM syndrome scores were significantly improved after treatment in both groups(P<0.01).Compared with the control group,the TCM syndrome scores of the study group were significantly lower than those of the control group,and the study group improved the TCM symptom scores.In the control group(P <0.01).6.Blood lipid levels: After treatment,the levels of serum TC,TG,LDL-C decreased and HDL-C levels increased(P<0.01).Comparison between groups,TC,TG,LDL-C after treatment in the study group The level was significantly lower than that of the control group and the HDL-C level was significantly increased(P<0.01).7.Serum hs-CRP levels: serum hs-CRP levels decreased after treatment(P<0.05).The serum hs-CRP levels in the study group were significantly lower than those in the control group(P<0.05).8.fibrin: After treatment,the levels of fibrinogen decreased in the two groups(P<0.05).Compared with the control group,the fibrinogen levels in the study group were significantly lower than those in the control group(P<0.05).9.Safety indicators: No adverse reactions occurred in the two groups of patients after taking the drug,and the indicators were also within the normal range.In conclusion:According to clinical research and analysis,Fufang Sanqi Humai Decoction can improve the clinical symptoms and clinical indexes of patients with stable angina pectoris.The combination of traditional Chinese and western medicine can not only improve the curative effect,but also be safe and effective.It has broad application prospects and is worthy of further clinical research. |
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