| Objective: This paper takes 287 cases of determined PLC inpatients in liuzhou hospital of traditional Chinese medicine as research target,retrospectively analyzes its general condition,clinical symptoms,syndrome differentiation of TCM,Chinese traditional treatment's effecton PLC,lifetime and affecting prognostic factor etc,deepens cognition of PLC,and guides PLC diagnosis and treatment.Methods: This research takes 287 cases of determined PLC patients,who are all inpatients of liuzhou hospital of traditional Chinese medicine from March 1st 2007 to October 31 st 2016,and accept treatment by Chinese herbs.All measurement data information adopts SPSS22.0 software for a statistical analysis and process.Results:1.Gender:238 males,49 females,the male female ratio is 4.85:1.2.Onset age and distribution interval: minimum age of onset is 19,maximum one is 82,meso-position one is 53;among which three cases between the age of 0 and 19,occupy 1.04%;66 cases between the age of 20 and 39,occupy 23.00%;146 cases betweent he age of 40 and 59,occupy 50.87%;46 cases between the age of 60 and 79,occupy 16.02%;26 cases with the age of over 80,occupy 9.07%.3.Etiological factor: 160 cases of hepatitis virus infection associated liver cancer,occupies 55.74%(therein 109 HBV-related cases,occupy38.0%;41 HCV-related cases,occupy 14.3%;10 cases of HBV/HCV concurrent infection association,occupy 3.44%);70 cases of alcohol associated liver cancer,occupy 24.39%;57 cases of other factor caused liver cancer,occupy 19.87%.4.Pathological type: among 142 patients in pathological diagnosis,there are 131 cases of hepatocellular carcinoma(HCC),occupying92.25%;7 cases of intrahepatic cholangiocarcinoma(ICC),occupying 4.93%;4 cases of mixed-type liver cancer,occupying 2.82%.5.Clinical stages: among 287 PLC patients,stage 0 has 47 cases,occupying 16.38%;stage A has 89 cases,occupying 31%;stage B has 74 cases,occupying 25.79%;stage C has 22 cases,occupying7.67%;stage D has 55 cases,occupying 19.16%;there are 60 cases with distant metastasis,among which there are 31 cases with pulmonary metastasis,15 cases with brain metastasis,8 cases with osseous metastasis,6 cases with pancreas metastasis.6.Chinese traditional medicine type: there are 99 cases with syndrome of interblend dryness and dampness,yin deficiency if liver and kidney,occupying 34.51%;67 cases with syndrome of insufficient spleen and over-abundant dampness,occupying 23.34%;47 cases with syndrome of liver and gallbladder damp-heat,occupying 16.37%;40 cases with Qi-stagnation and blood stasis,occupying 13.93%;34cases with syndrome of stagnant heat toxin and obstructed tri-jiao,occupying 11.85%.7.Most inclusive patients have main syndromes of spiritual and power fatigue,emaciation,reduced appetite,poor dormancy,pain,abdominal discomfort etc,among which there are 210 cases with spiritual and power fatigue,192 cases with emaciation,173 cases with reduced appetite,171 cases with poor dormancy,162 cases with yellow urinate etc.8.Total improvement rate of KPS is 66.20%,and the improvement rate of patients with KPS of over 60 is 69.18%,the improvement rate of patients with KPS of less than 60 is 63.12%,the improvement rate of Qi deficiency and blood stasis is 75%.9.Symptomatic improvement rate: 78.98% of edema,76.19% of spiritual and power fatigue,75% of pain,72.84% of yellow urinate,71.02% of abdominal discomfort,68.20% of reduced appetite,66.14% of emaciation,65.81% of dry stool,61.40% of poor dormancy.10.Total median survival time is 367 days,the survival rate of one year,two years,three years,five years are:50.10%?23.25%?18.10%,8.55%;and the survival rate of taking traditional Chinese medicine for a long time is higher than the short one.11.Cox multi-factor analysis shows that factors singly affecting on patients' lifetime are serum's AKP?LDH?GGT level and liver function Child-Pugh classification.Conclusions: The morbidity of PLC male is obviously higher than the female's in our hospital,hepatocellular carcinoma attaches most importance,most onset age concentrates between the age of 40 and59,and appears the trend of aging development;hepatitis B virus chronic infection is the most common-seen etiological factor of PLC in our hospital;the majority of patients have been on the middle and late period when disease appears,which miss the best treatment chance;AKP?LDH?GGT level of serum and Child-Pugh classification of liver function are prognosis-related factors;after taking traditional Chinese medicine,KPS total improvement rate of 287 cases of PLC patients is 66.20%,and improvement rate of patients with more than 60 KPS is preferable,improvement rate of Qi deficiency and blood stasis is highest.Symptom relieves more than before,such as strengthen physical power,relieve edema and partial pain,but as some patients are heavily sick,the effect is not good enough,after taking traditional Chinese medicine,the common symptom of 287 PLC patients gets better,there is a difference in mend matters of different symptom scores,therein the mend matters of symptom score 1 is most obvious.Total median survival time is 367 days,the survival rate of one year,two years,three years and five years respectively are 50.10%?23.25%?18.10%,8.55%,it can improve survival rate to persist in taking traditional Chinese medicine;in terms of improving survival quality,traditional Chinese medicinet reatment has an obvious effect. |
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