Research On The Compatibility Principles Of Drugs In Secret Formulary For Traumatology And Fracture Taught By Immortal

ObJective: The full reading of the original,based on the relevant literature review,the prescription information in Secret Formulary for Traumatology and Fracture Taught by Immortal of Lin Daoren performed by digital processing,using modern information technology to carry out multi angle,multi-level,full range analysis,statistics,to refine the Secret Formulary for Traumatology and Fracture Taught by Immortal collection contains all independent formulae implied by the intrinsic link inductive drug laws,with a view to a more accurate grasp of Lin daoren in treatment of traumatic fracture of main academic thoughts,the basic principles of prescription,in order to make the past serve the present,to enhance integration of traditional Chinese medicine and modern clinical level,for the benefit of more patients.Methods:1 By people’s Medical Publishing House,2006.The first edition,in October 2012 the 3rd printing "Chinese clinical reading series" Secret Formulary for Traumatology and Fracture Taught by Immortal "as the research object,Secret Formulary for Traumatology and Fracture Taught by Immortal " to block printed editions of the Hongwu Period,any text accord to the hongzhichongdetang or Text-prof by the ‘dao cang’ of the Ming period.2 To read the original work,based on the understanding of the original text,contained in 46 of medicine and medicine groups,such as prescriptions,multilayer analysis and other agents in the treatment of the name,quantity do standardized treatment,on drug use and compatibility of digital statistics,and analysis,summarized the effectiveness of each prescriptions,and indications related information.3 Choose Foxtable2014 data management software as the statistical tools,prescription and the study of the literature related to information,conversionto digital information are input to the software,the establishment of " Secret Formulary for Traumatology and Fracture Taught by Immortal " prescription information database ".4 Carrying out statistical analysis on the information in the database using Foxtable2014 data management software "screening","summary","computation" and other functions,including drug use frequency,average dose,prescriptions per dose,treatment group of frequency of use,and the statistical analysis.Results:1 Secret Formulary for Traumatology and Fracture Taught by Immortal records the basic situation of the prescription: Secret Formulary for Traumatology and Fracture Taught by Immortal contain 46 prescriptions.36 oral prescriptions,10 external application of the herbal,the formula used involving a total of 131 drugs,21 of the drugs for promoting blood circulation and removing blood stasis,18 drugs of tonic medicine.14 drugs of diaphoretics,9 drugs of warming inside,9 drugs fo regulating breath,8 drugs of antitussive and antiasthmatic and 8 drugs of heat clearing.Total of the book,the largest number of medicine is Glechoma,medication 30 drugs,The least number of prescription drug is only 1 drugs used osteopathic medicine.Secret Formulary for Traumatology and Fracture Taught by Immortal prescription are powder and pills,drug taste is higher than the number of 10 drugs of the 23 songs,accounted for 50% of the total songs of the book and to10-15 drugs composition a dose to each service 5g-10 g,average weight of each herb used for 1g-2g.2 Secret Formulary for Traumatology and Fracture Taught by Immortal recorded in the prescription of the efficacy and indications of the original 46 prescriptions,31 prescriptions have "blood active" effect,in addition,each of the "buyang" and "qingre"19,"dampness" 15,"rheumatism" 12,"zhixue" and"liqi" 11,"insecticide" 10,"buqi" 9,while the remaining effects such as buyin,Xiexia,astringent,xifeng,calm nerves,resuscitation,digestion are blowe 9prescriptions.On indications,37 prescriptions have "blood stasis" in total 46,19 prescriptions have"cold coagulation syndrome,phlegm 17,asthenia16,waiganfengxie 13,but in others such as wet evil invasion and qizhi are 9prescriptions,inverse gas and rezheng are each 4 prescriptions,malarial pathogen is one prescriptions.The results showed that the Secret Formulary for Traumatology and Fracture Taught by Immortal Pay attention to blood stasis injury pathogenesis,diagnosis on activating blood prescription.3 In the Secret Formulary for Traumatology and Fracture Taught by Immortal,the frequency and dose of drug use: the original 46 prescription drug involved 131 herbs,used a total of 449 time.Among them,the highest frequency of use for Danggui,27 prescriptions,Chuanwu 18 prescriptions,Achyranthes bidentata 17,cinnamon 16,Rhizoma Drynariae and Chuanxiong were 14,Asarum 13,Peony,Angelica and kikyou were 12,Hershouwu 11 prescriptions,Arisaema 10,the rest of the drug were less than10.In the use of the highest frequency of 10 kinds of drugs,Chuanxiong and Niuxi can promoting blood circulation to remove blood stasis,Danggui,Gusuibu and Baishao can solution table,Xixin and Baishao can jiebiao.A dose of the drug in the original drug involved a total dose of 625.74 g,the most dose of a single drug are Danggui 30.408 g,Chuangwu 29.190 g,Platycodon Radix Aconiti 24.690 g,pinellia 21.803g(3 prescriptions),momordic 20.686 g,Polygonum 17.434 g,Radix Paeoniae Alba 16.925 g,black 16.754 g,Dilong16.012g(3 prescriptions),Meiyao 15.867 g,licorice 15.127 g,Cangzhu15.031 g,Niuxi 14.386 g,Tiannanxing 13.989 g,Houpu 12.952g(3prescriptions),taking into account the half summer,Dilong,magnolia bark and other drug use frequency too less,therefore,the average dose of single drug black beans,momordica seed,Platycodon root,Atractylodes rhizome,myrrh,Polygonum multiflorum,liquorice,tangerine peel,Radix Aconiti,red bean,Araceae,Radix Paeoniae Alba,Radix Linderae,Aconitum,angelica,blood tonic,Wen Li And expectorant drugs dosage is still in the top.4 Determine the monarch drug of the Secret Formulary for Traumatology and Fracture Taught by Immortal: promoting blood circulation drug as monarch drug in 17 songs,frankincense and myrrh as monarch drug 3 songs,Chuanxiong,Radix Achyranthis Bidentatae for monarch drug 2,Herba Lycopi,jaws,Liquidambar,poplar bark,Rhizoma sparganii,Rhizoma Corydalis,pangolin drugs were used as monarch drug one time.Buxu drugs as monarch drug in 17 songs,Danggui and Heshouwu as monarch drug 6 songs,Gusuibu for monarch drug 2,Xuduan,Biejia,Shudi were used as monarch drug one time.the temperature in medicine as monarch drug 9 songs,including Chuanwu as monarch drug 5 song to the Aconitum,as monarch drug3 song to aconite,monarch drug and expectorant cough and asthma medicine as monarch drug 6;to heat clearing drugs for the monarch drug 5;Liqi drugs for the monarch drug 4;to cathartic,rheumatism medicine for monarch drug 3;in medicine for the monarch drug 2;to the wet aroma drugs,drugs for inducing resuscitation,attack insecticidal antipruritic drugs as monarch drug were one time.More than 1/3 prescriptions to remove blood stasis drugs,tonic medicine as monarch drug,and to warm in medicine as monarch drug,is not in the minority.5 The record of prescription drug compatibility analysis results of Secret Formulary for Traumatology and Fracture Taught by Immortal: two herbs combined with structure in the original 46 prescriptions,followed by angelica and Achyranthes 15 songs;Chinese angelica and Rhizoma Drynariae,Radix Angelicae and sinensis,Radix and Aconiti,angelica and cassia,angelica and Chuanxiong,Drynaria and Achyranthes,Radix and Aconiti are 13 songs;angelica and asarum 12 songs,Chinese angelica and Radix,Paeoniae and Alba,Achyranthes root and asarum are 11 songs;angelica and angelica,angelica and Radix,Polygoni Multiflori and Radix Angelicae sinensis,Platycodon root and Achyranthes,Polygonum and aconite root,Rhizoma Drynariae and cinnamon,Rhizoma Chuanxiong and Rhizoma as arum are 10 songs and so on.Three medicines combination structure are angelica Radix,Achyranthis Bidentatae and Rhizoma Drynaria 12 songs,Chinese angelica,Achyranthes and Radix Aconiti 11 songs,angelica,Achyranthes root and as arum;angelica,cassia bark and Rhizoma Chuanxiong 10 songs,angelica,Achyranthes andPolygonum;angelica,cinnamon bark and as arum;Radix Achyranthis Bidentatae,Rhizoma Drynariae and Radix Aconiti;angelica 、 Rhizoma Drynariae and as arum;angelica,Rhizoma Drynariae and Radix Aconiti;angelica,cassia bark and Radix Angelicae dahuricae were 9 songs.Compatibility of four herbs structure is the most "angelica,Achyranthes root,Rhizoma Drynariae,asarum",angelica,Radix Achyranthis Bidentatae,Rhizoma Drynariae,Radix Polygoni Multiflori ",angelica,Radix Achyranthis Bidentatae,Rhizoma Drynariae,Radix Aconiti" and angelica,Achyranthes root,asarum,cinnamon "is the first 8," angelica,Rhizoma Drynariae,asaryl,Polygonum,angelica,Rhizoma Drynariae,asarum,cinnamon ",angelica,cassia bark,Rhizoma Chuanxiong,Radix Angelicae dahuricae",angelica,Achyranthes root,Sichuan aconite root,asarum ",angelica,Radix Achyranthis Bidentatae,Rhizoma Drynariae,Arisaema",angelica,cinnamon,dahurian angelica root,Platycodon grandiflorum and were the first 7.Five medicines combination structure is the most "angelica,Achyranthes root,Rhizoma Drynariae,asarum herb,Polygonum 7 songs," angelica,Achyranthes root,Rhizoma Drynariae,asarum,cinnamon ",angelica,cassia bark,chuanxiong rhizome,dahurian angelica root,Platycodon grandiflorum",angelica,Achyranthes root,asarum,cinnamon,Chuanxiong ",angelica,Achyranthes root,asarum,cinnamon,Radix Angelicae dahuricae",angelica,Achyranthes root,asarum,cinnamon,Radix Paeoniae Rubra ",angelica,Radix Achyranthis Bidentatae,Rhizoma Drynariae,asarum,Arisaema" and angelica,Achyranthes root,Rhizoma Drynariae,radix and Rhizoma Chuanxiong "were6 songs and so on.These results showed that the compatibility drug concentration is high,the tonic medicine mainly Chinese angelica,Rhizoma Drynariae,promoting blood circulation to remove blood stasis mainly Achyranthes root,Ligusticum chuanxiong Hort,warm in medicine mainly cinnamon,aconite,medicine mainly for asarum,Angelica dahurica,antitussive,expectorant and antiasthmatic drugs mainly Platycodon root,Arisaema.Mainly in the compatibility between tonic medicine,promoting blood circulation to remove blood stasis.In addition these two types of drugs and the temperature in drugs,medicine,expectorant,antitussive and antiasthmatic drug compatibility of high frequency table.Conclusion:1 Secret Formulary for Traumatology and Fracture Taught by Immortal containing a total of 46 square,inside drugs 36 songs and outside drugs 10 songs.medication flavor of the largest number of is Glechoma and medication30 flavor,taste of medication the least number of is bone setting medicine and osteopathic medicine,medicine blindly,the majority with a number of ingredients for 10-15 flavor.2 Drug use most frequently is the complement virtual drugs,Angelica sinensis,up to 28 times and frequency of use for more than 10 times and drugs for Sichuan aconite root,Achyranthes root,cassia bark,Rhizoma Drynariae,Rhizoma Chuanxiong,Herba asari,white peony root,dahurian angelica root,Platycodon root,fleece flower root,Arisaema.Thus,Lin daoren treatment of traumatic fracture disease use invigorate the circulation of blood and blood products,and reasonable application of the large number of solution is obtained in the form of medicine,warm in medicine and expectorant,antitussive and antiasthmatic drug.3 Compatibility drug concentration is high,the tonic medicine mainly Chinese angelica,Rhizoma Drynariae,promoting blood circulation to remove blood stasis mainly Achyranthes root,Ligusticum chuanxiong Hort,warm in medicine is mainly cinnamon,aconite,medicine mainly for asarum,Angelica dahurica,antitussive,expectorant and antiasthmatic drugs mainly Platycodon root,Arisaema.Mainly in the compatibility between tonic medicine,promoting blood circulation to remove blood stasis.In addition these two types of drugs and the temperature in drugs,medicine,expectorant,antitussive and antiasthmatic drug compatibility of high frequency table.4 The original prescription to promoting blood circulation and removing blood stasis and tonifying drugs for the monarch drug,followed by temperature in medicine and expectorant,antitussive and antiasthmatic drugfor the monarch drug,and other types of drugs for the kings are less.Thus,Lin daoren in the diagnosis and treatment of injuries from the whole view,pay attention to blood tonic and expectorant.5 The original prescription to promoting blood circulation and removing blood stasis and tonifying drugs for the monarch drug,followed by temperature in medicine and expectorant,antitussive and antiasthmatic drug for the monarch drug,and other types of drugs for the kings are less.Thus,Lin daoren in the diagnosis and treatment of traumatic stasis by activating blood for the treatment of the main method.