| Objective:UACS(upper airway cough syndrome)is a common cause of chronic cough. The study through observe the curative effect of Small bupleurum tonga subtraction combined with conventional western medicine treating UACS, which based on the treatise on febrile diseases, to explore the curative effect of the cooperation of Chinese and western medicine treatment and provide the basis for further improve UACS clinical curative effect.Methods:109 patients with cough caused by UACS were selected. These patients were diagnose Less evil guest Yang syndrome in accordance with the diagnosis and treatment criteria of cough of UACS in the guide(2009 edition) [1] and the diagnosis and differential diagnosis of TCM.109 patients were randomly divided into treatment group 55 cases and control group of 54 cases.They were did conventionally chest imaging examination and blood routine examination in the first time to see a doctor to eliminate organic disease such as lung cancer, respiratory system. And to ensure basically identical of two groups of patients in terms of age, sex, course of the disease and complications. In the process of observation,there were four cases of treatment group fall off and three cases of control group fall off. These fall off cases is not included in the efficacy of statistics. The remaining 102 cases have completed the research.The control group was given conventional western medicine treatment. includes: Ebastine Tablets 10 mg qd, 10 m L of compound glycyrrhiza oral solution 3 times/day; Treatment 2 weeks. 7 days for a period of treatment, observation 1-2 period of treatment.The treatment group was given Xiao Chai Hu decoction adjusted treatment combined with aforementioned conventional western medicine. The essential medicines for Xiao Chai Hu decoction were 12 g radix bupleuri, 15 g radix scutellariae, 12 g dang shen, 15 g pinellia, 6g licorice, 15 g almond, 15 g platycodon grandiflorum, 15 g radix peucedani, 5-8ghoney ephedra, and 6-10 g schisandra. Daily 1 agent, water frying three times, tid, and 7 days for a period of treatment, observation of 1-2 period of treatment.Add and subtract according to the different symptoms. And a stuffy nose, runny nose add xanthium, magnolia flower and asarum; Cough obviously with almonds, platycodon grandiflorum. ephedra, schisandra. Yellow viscous sputum add white mulberry root-barkh, cordata; chest tightness and nausea add cortex trichosanthis, fructus aurantii; Dry throat itching, sputum junior add fructus arctii, radix isatidis, radix ophiopogonis; And headache add angelica, radix puerariae, rhizoma ligustici wallichii. Easy to catch a cold, afraid of the cold, encounter cold prone, combined with astragalus membranaceus, Saponikovia cata, atractylodes.The treatment effects of two groups were observed after three days, seven days, fourteen days and two weeks after the cured. Comparison before and after treatment hepatic function(ALT, AST) and renal function(BUN, Cr), analyze these data use SPSS17.0 statistical software.Results : Two groups of patients before symptoms integral average contrast t = 0.957, P > 0.05, there was no statistically significant difference.(1) Clinical efficacy: 3 days after treatment, treatment group effective rate was 72.5%, the control group effective rate effectiveness was58.8%;7 days after treatment, the treatment group effective rate was 86.2%, control group 78.4%; 14 days after treatment, the treatment group effectiveness 90.19%, control group was 82.3%;significantly difference compare with the two groups in the three times(P < 0.05).(2)Symptoms integral: two groups of symptoms before and after the treatment, according to the integral mean value contrast treatment group(P < 0.01), there was an obvious statistical significance difference; Control group(P < 0.05), the difference was statistically significant.(3) Follow-up: 2 weeks after the end of the treatment, the effective rate of the treatment group was 92.1%, and control group was 82.3%. Compared with the efficacy at the end of the course, only slight difference, P values > 0.05, no statistical significance.(4) Treatment time comparison:The cured and markedly effective rate in 3 days after treatment was 41.1% in treatment group and 13.7% in control group. Difference value of the two group was 27.4%; in 7 days after treatment was 72.5% and47.0%. Difference value of the two group was 25.5%; in 14 days after treatment was 78.4% and 64.7%. Difference value of the two group was 13.7%; Two groups of cured and markedly effective rate in 3 days after treatment have obvious difference. That the cured and markedly effective rate is higher in treatment group than the control group, not only effect faster.Three- time test by chi-square, there were markedly difference, P values < 0.01, but the gap was decreasing. That combine traditional Chinese and western medicine treatment group not only higher than that of pure western medicine treatment, can also shorten the course of time.Conclusion:(1) For these patients with UACS, which diagnosed a little Yang syndrome through TCM syndrome differentiation, clinical curative effect that with a small radix bupleuri tonga subtraction combined with conventional western medicine treatment is superior to pure western medicine treatment.(2) For these patients, clinical symptoms improved that with a small radix bupleuri tonga subtraction combined with conventional western medicine treatment is better than western medicine treatment.(3) For these patients, with a small radix bupleuri tonga subtraction combined with conventional western medicine treatment could shorten the treatment time, stable curative effect, and the recurrence rate is also low.(4) The therapeutic schedule had no effect on the liver and kidney function, and it was safety. |
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