TCM Mechanisms Of Ma-huang Decotion And Gui-zhi Decotion On Molecular Level

Ma-huang Decoction and Gui-zhi Decoction are widely used Traditional Chinese Medicines (TCM) which have been extensively applied in treatment of Wind-attack Syndrome of Taiyang and Typhoid Syndrome of Taiyang. However, the underlying mechanism and GZD and MHD's systems-level characterization of drug-target associations are still unknown because each of herb has hundreds of compounds and corresponding targets.In this work, the two herbs were studied to elucidate why both of them ameliorate perspiration in Wind-attack Syndrome of Taiyang and Typhoid Syndrome of Taiyang. We have constructed a computational approach by combining oral bioavailability screening, drug-likeness prediction and network pharmacology analysis, which uncovers the principle of perspiration in Wind-attack Syndrome of Taiyang and Typhoid Syndrome of Taiyang. The pharmacological system comprises 93 bioactive ingredients and 36 potential targets related to perspiration in GZD and MHD. Our results suggest that the MHD brings into play possibly through adrenergic effect, vasodilation, and smooth muscle contraction while GZD via anti-inflammation, cholinergic inhibition, vascular permeability decreasing and vasoconstriction.As an emerging approach, the proposed systems pharmacology model facilitates elucidation the mechanism of the complex prescriptions, which may make a contribution to new development for alternative medicine.