Feasibility Study On Feline Heterologous Canine Transfusion And Clinical Efficacy During Acute Hemorrhagic Shock

Blood transfusion is a treatment which inputs healthy blood or blood components for blood enrichment,hemostaticand detoxification.As a kind of effective rescue methods,it is widely used in clinical diagnosis and treatment.Heterologous transfusion is between different species of animals.The blood includes whole blood,blood components and blood products.This test explores the feasibility of feline heterologous canine transfusion,and evaluates its remedial effects on the treatment of feline acute hemorrhagic shock.Our research will provide guidance for its application in the pet clinic.Test ? The feasibility study of feline heterologous canine transfusionThe test was conducted to evaluate the feasibility of feline heterologous canine transfusion.Eighteen healthy adult felines(average weight = 4 ± 0.5 kg)were selected and randomly divided into three groups.They were respectively set the control group A(intravenous infusions),the group B(intravenous transfusion of feline whole blood),the group C(intravenous transfusion of canine whole blood).Total fluid was about 20%of the total blood volume of the test animals.Clinical manifestations were observed.Hematological,blood biochemical and electrolyte parameters,and urinalysis were compared on the 2 h before the test,0.5 h,1 h,2 hand 7 consecutive days after infusion.The result shows that there is no significant difference among the group A,Band C(P>0.05).Test ? The establishment of the feline acute hemorrhagic shock model9 healthy adult felines(average weight=4±0.5 kg)were selected,and took the before-after study.Establish the model by bleeding from cardiac.Specific methods:the felines were bled from cardiac by 20 ml/kg after sedation.Clinical symptoms were observed throughout the trial period.Hematological,blood biochemical and electrolyte parameters,and urinalysis were compared on 30 min before the test,Omin,15 min,30 min after the bloodletting.Results:9 felines were successfully established model of the acute hemorrhagic shock.The temperature dropped,heart rate increased,visible mucous membranes pale,mental fatigue,significantly reducing waste and other symptoms of feline occurred after acute hemorrhage.Compared with the previous model preparation(T01),the values of lymphocytes,monocytes,neutrophils,erythrocytes,hemoglobin and hematocrit,the concentration of Na+,K+,Cl-and the blood pressure on 30 min(T30)after the bloodletting decreased significantly,even outside the normal range.The difference was significant(P<0.05).The result shows that bloodletting from cardiac allows rapid establishment of a reliable feline model of acute hemorrhagic shock.Test ? Clinical efficacy of feline heterologous canine transfusion during acute hemorrhagic shockTo explore the clinical efficacy of feline heterologous canine transfusion during acute hemorrhagic shock,9acute hemorrhagic shock felines were randomly divided into three groups.Three groups were set:the control group A(intravenous infusions),the group B(Aand intravenous transfusion of feline whole blood)and the group C(A and intravenous transfusion of canine whole blood).Assess the effect of feline heterologous canine transfusion on the treatment of feline acute hemorrhagic shock through the observation of clinical symptoms,results of blood,blood biochemistry and electrolytes and comparison on the 2 h before test,the 2 h,1 d,3d,7 d,14 d after infusion.There was significant difference in the parameters of the group A and B,also A and C(p<0.05),respectively.However,the difference between the group Band C was not noteworthy(p>0.05).Though the whole test,no blood-related adverse reactions appeared.The results suggest that feline heterologous canine transfusion during acute hemorrhagic shock is curative.