Lung Nasal Stagnation Treat Asthma Combined The Clinical Effect Of The Treatment Of Allergic Rhinitis

Objective:Investigating the effect of combine traditional Chinese and western medicine on asthma patients with allergic rhinitis, and compare with the simple western medicine, to evaluate the clinical effects of "together treatment of lung and nose" for patients with sensitive rhinitis complicated with asthma. In this study, an attempt was made to find the treatment of combining traditional Chinese and western medicine that can improve the patients’ clinical symptoms, lung function, laboratory index, reduce the acute episode frequency and alleviate disease progression, which could be applied and generalized in clinic.Method:By the way of retrospective controlled study,60 patients (inpatient and out patient) who have asthma complicated with allergic rhinitis under treatment in The First Affiliated Hospital of Guangdong University of Traditional Chinese Medicine respiration department during the February and October 2015, were randomly divided into control group and treatment group,30 for each group. The control group was treated with Loratadine, Montelukast and Symbicort turbulaler while the treatment group treated with both western medicine and traditional Chinese medicine. Observe and compare the clinical effects, curative effect and the frequency of acute episodes of the two groups.Results:1. In both the control group and the treatment group, the peripheral blood EOS content, exhaled nitric oxide content and serum IgE levels were decreased after 12 weeks of treatment. There were statistically significant differences in the two groups of patients after treatment (P <0.01). Compared the before-after change value of the two groups, the peripheral blood EOS content changes P< 0.01. Exhaled nitric oxide content and serum IgE levels change values P<0.05.2. After 12 weeks of treatment, the pulmonary function of the two group patients were all improved, mostly in FEV1%(P<0.01). Before and after treatment, the change values of the treatment group were significantly different than that of the control group (P<0.01)3. After 12 weeks of treatment, the total effective rate to control asthma attack in the treatment group was 96.7% while it was 66.7% in the control group. The asthma controlling rate in the treatment group was significantly higher than that of the control group (P< 0.05). The total effective rate of allergic rhinitis curative effect in the treatment group was 96.7% while it was 60.0% in the control group. Which was significantly higher than that of the control group (P< 0.05). The total effective rate of allergic rhinitis curative effect in the treatment group was 96.7% while it was 80.0% in the control group. Which was asthma higher than that of the control group (P＜ 0.05). The total effective rate of allergic rhinitis curative effect in the treatment group was 96.7% while it was 73.3% in the control group. Which was asthma-significantly higher than that of the control group (P< 0.05).4. During the treatment, the acute attack rate of patients in the control group was 27%,1 patient was hospitalized for acute attack,7 have received outpatient treatment. The acute attack rate in the treatment group was 6.7%,2 patients had outpatient treatment and no inpatient treatment. Through the Chi-square test of acute episodes during treatment, two groups have no significant difference (P>0.05). For follow-up of 1 month,4 patients in the control group have received outpatient treatment in acute attack, and there was only one patient in the treatment group of that, both of the 2 groups have no acute attack to hospitalization. The Chi-square test shows no significant difference between the two groups’ acute attack frequency during the follow-up period (P> 0.05).Conclusion:For patients with sensitive rhinitis complicated with asthma, "together treatment of lung and nose" can not only improve patients’the pulmonary function, decrease serum IgE levels, exhaled nitric oxide content and peripheral blood EOS content, but also reduce the number of acute attacks and alleviate disease progression, which would lead to airway remodeling and ACOS.