Observation Of Bone Tissue Regeneration In The Research Of Growth Factor Preservated In Periodontitis Sites

Objective The ability of platelet-rich fibrin (PRF) and basic fibroblast growth factor (bFGF) to promote bone formation was comparedto observe their differences.Methods 28 cases with periodontitis, whose loose teeth couldn’t be retained and then were removed, were randomly divided into three groups. The PRF group was filled with the mixure of Bio-Oss and PRF in the alveolar fossa. The bFGF group was used bFGF and Bio-Oss, and the blank group was only added Bio-Oss. The clinical measurements of changes in bone resorption in the surgical area, average value of bone density, bone height of adjacent teeth were done after six months of operation. The diameter of 2.5mm and 4mm long bone specimens were taken out from PRF and bFGF groups to be observed. And the professional image analysis software IPP.6.0 was used to conduct quantitative analysis of the new growth quantity.Results The quantity of vertical bone absortption was 0.98±0.20 in blank group, that in PRF group was 0.63±0.11, and that in bFGF group was 0.72±0.22. There was no significant difference in bone height between bFGF group and PRF group. The blank group was analyzed with PRF group and bFGF group respectively, and the differences were statistically significant. The average value of bone density was 369.06±35.23 in blank group, that in PRF group was 854.06±69.35, and that in bFGF group was 597.52±138.87. There was a significant difference in the average value of bone density between bFGF group and PRF group. The blank group was analyzed with PRF group and bFGF group respectively, and the differences were statistically significant. The Changes of alveolar bone height in adjacent teeth was 0.52±0.16 in blank group, that in PRF group was 1.03±0.11, and that in bFGF group was 0.94±0.17. There was no significant difference in Changes of alveolar bone height in adjacent teeth between bFGF group and PRF group. The blank group was analyzed with PRF group and bFGF group respectively, and the differences were statistically significant. Percentage of newly formed bone was measured by using the professional image analysis software IPPP.6.0., that in blank group was 24.2±2.2, that in PRF group was 48.3±9.1,and that in bFGF group was 37.6±5.0. The blank group was analyzed with PRF group and bFGF group respectively, and the differences were statistically significant, therefore it could tell that the generation capacity of PRF group to promote osteogenesis was higher than that of bFGF group.Conclusion PRF can more effectively promote the formation of bone tissue, which can obtain more new bone, and provide a good environment for implant restoration.